Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Fabrication and Characterization of Methylprednisolone-Loaded Polylactic Acid/Hyaluronic Acid Nanofibrous Scaffold for Soft Tissue Engineering Publisher



Keikha M1, 2 ; Entekhabi E3 ; Shokrollahi M4 ; Nazarpak MH4 ; Hassannejad Z5 ; Akbari S6 ; Vaccaro AR7 ; Rahimimovaghar V1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Chemical Engineering Department, Amirkabir University of Technology, Tehran, Iran
  3. 3. Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran
  4. 4. New Technologies Research Center (NTRC), Amirkabir University of Technology, Tehran, Iran
  5. 5. Pediatric Gene, Cell & Tissue Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran
  7. 7. Department of Orthopedics and Neurosurgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA, United States

Source: Journal of Industrial Textiles Published:2022


Abstract

Previous in vitro and in vivo studies have indicated that tissue engineering scaffolds, including Schwann cells, may improve axonal regeneration, particularly in combination with Methylprednisolone as an influential neuroprotective factor. The primary aim of this study was to design composite electrospun scaffolds based on polylactic acid (PLA)/hyaluronic acid (HA) containing various percentages (0.05–2% (w/v)) of Methylprednisolone (MP) with suitable mechanical and chemical properties for soft tissue especially to promote nerve growth. For the first time, MP was implicated in a PLA/HA nanofibrous and its effect on fiber’s properties was scrutinized as a candidate for nerve tissue engineering. In addition, morphology, chemical bonding, wettability, and degradation of the scaffolds were examined to evaluate their performance. The results showed the PLA/HA scaffolds had suitable morphological, physicochemical, and mechanical properties for nerve regeneration. Also, various percentages of MP were evaluated through physiochemical assay, drug release profile, and biological assays to find an optimum level of drug. These scaffolds may improve the growth and viability of Schwann cells. Results showed that composite scaffolds containing 0.5 w/v MP had lower cytotoxicity and higher biocompatibility. © The Author(s) 2022.
Related Docs
View other Related Docs
1. Fabrication and in Vitro Evaluation of 3D Composite Scaffold Based on Collagen/Hyaluronic Acid Sponge and Electrospun Polycaprolactone Nanofibers for Peripheral Nerve Regeneration, Journal of Biomedical Materials Research - Part A (2021)
2. Tailoring Synthetic Polymeric Biomaterials Towards Nerve Tissue Engineering: A Review, Artificial Cells# Nanomedicine and Biotechnology (2019)
3. Advanced Approaches to Regenerate Spinal Cord Injury: The Development of Cell and Tissue Engineering Therapy and Combinational Treatments, Biomedicine and Pharmacotherapy (2022)
4. Chitosan Nanoparticles, As Biological Macromolecule-Based Drug Delivery Systems to Improve the Healing Potential of Artificial Neural Guidance Channels: A Review, International Journal of Biological Macromolecules (2022)
5. Biomimetic Engineered Approaches for Neural Tissue Engineering: Spinal Cord Injury, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2023)
6. Sciatic Nerve Regeneration by Using Collagen Type I Hydrogel Containing Naringin, Journal of Materials Science: Materials in Medicine (2019)
7. An in Vitro and in Vivo Study of Electrospun Polyvinyl Alcohol/Chitosan/Sildenafil Citrate Mat on 3D-Printed Polycaprolactone Membrane As a Double Layer Wound Dressing, International Journal of Biological Macromolecules (2024)
8. Preparation of Bilayer Tissue-Engineered Polyurethane/Poly-L-Lactic Acid Nerve Conduits and Their in Vitro Characterization for Use in Peripheral Nerve Regeneration, Journal of Biological Engineering (2024)
Experts (# of related papers)
View all Related Experts
Somayeh Ebrahimi Barough (2)
Zahra Hassannejad (1)
Other Related Docs
9. In Vitro and in Vivo Studies of Biaxially Electrospun Poly(Caprolactone)/Gelatin Nanofibers, Reinforced With Cellulose Nanocrystals, for Wound Healing Applications, Cellulose (2020)
10. Electrospinning of Polyvinyl Alcohol/Chitosan/Hyaluronic Acid Nanofiber Containing Growth Hormone and Its Release Investigations, Polymers for Advanced Technologies (2021)
11. Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process, Central Nervous System Agents in Medicinal Chemistry (2018)
12. Recent Advances in Enhances Peripheral Nerve Orientation: The Synergy of Micro or Nano Patterns With Therapeutic Tactics, Journal of Nanobiotechnology (2024)
13. A Facile Route to the Synthesis of Anilinic Electroactive Colloidal Hydrogels for Neural Tissue Engineering Applications, Journal of Colloid and Interface Science (2018)