Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process Publisher Pubmed



Shabeeb D^{1, 2} ; Najafi M³ ; Keshavarz M⁴ ; Musa AE¹ ; Hassanzadeh G⁵ ; Hadian MR⁶ ; Shirazi A¹
Source: Central Nervous System Agents in Medicinal Chemistry Published:2018

Abstract

Introduction: Peripheral nerve lesion is a common clinical problem that may produce long-term functional defects. Usually, crush injuries, fractures, scars, lacerations, compression, or iatrogen-ic reasons are reasons for nerve injuries. Unsuccessful treatment of nerve injuries causes partial or total loss of sense, motor, and autonomic functions. Despite widespread experimental studies that aimed to improve nerve healing, healing results for peripheral nerve injuries are hardly reasonable. The successes of the regenerative procedure of the nerve repair in experimental research, with topical agents, can be assessed using different methods such as morphological, electrophysiological, biochemical and functional evaluation. Although, most researchers confirm that despite good microsurgical repair and topical application of these substances, complete regeneration and functional recovery of the injured nerves are almost never achieved. Conclusion: This study aimed to make a comparison between topical pharmacological agents at the peripheral nerve lesion and methods used for evaluating the success of the repair process. For this purpose, we reviewed studies conducted on some of the most commonly used pharmacological agents as well as their properties in the repair of peripheral nerve lesions. © 2018 Bentham Science Publishers.