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Determinants of Survival of Common Childhood Cancers in Iran Publisher



Keramatinia A1, 2 ; Mohseny M2 ; Akbari ME1 ; Mosavijarrahi A3 ; Monfared ED6 ; Amanpour F11 ; Monfared AB2 ; Amiri P12 ; Khayamzadeh M1 ; Khoshnazar TAK1, 7 ; Abbaszadeh HA4, 8 ; Mehrvar A9, 10 ; Mazloumi Z13 ; Movafagh A5
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Health and Community Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Health and Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Community Medicine, Health Management Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  7. 7. Department of Nursing, School of Nursing and Midwifery, Tehran, Iran
  8. 8. Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Health and Community Medicine, AJA University of Medical Sciences, Tehran, Iran
  10. 10. MAHAK Pediatric Cancer Treatment and Research Center, Tehran, Iran
  11. 11. Department of Epidemiology and Biostatistics, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran
  12. 12. Iranian Research Center on Healthy Aging, Sabzevar University of Medical Scienses, Sabzevar, Iran
  13. 13. Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran

Source: Journal of Research in Medical Sciences Published:2018


Abstract

Background: Cancer is the second most common cause of morbidity and mortality in children. This study aimed to epidemiologically and demographically assess common cancers in children in Iran. Materials and Methods: This cohort study was conducted on children registered in Mahak Hospital and Rehabilitation Complex (which is a non-governmental organizations (NGO)-related hospital for only malignant diseases). A total of 2232 questionnaires were filled out for cancer patients between 2007 and 2016. The factors including age, gender, race, family history, type of treatment, and type of cancer were entered into Cox regression model to examine their effect on mortality of children diagnosed with cancer. Results: The Cox regression model showed that age, race, type of cancer, family history of cancer, and type of treatment had a significant effect on mortality of children diagnosed with cancer (P < 0.05). The hazard ratio (HR) of mortality in 10-15 years old was higher than that of 1-5 years old (P = 0.03, HR = 1.3). The HR of mortality in patients with brain tumor (P < 0.01, HR = 2.24), sarcoma (P < 0.01, HR = 2.32), and neuroblastoma (P < 0.01, HR = 2.56) was twice the value in patients with leukemia. The HR of mortality in patients who had a family history of cancer was higher than that of patients without it (P < 0.01, HR = 1.33). Patients who had undergone chemotherapy along with surgery and radiotherapy (P = 0.02, HR = 0.68) and patients who received chemotherapy along with surgery (P = 0.01, HR = 0.67) had a lower HR of mortality compared to the chemotherapy group. Conclusion: Young age, multidisciplinary approach, and absence of family history were associated with lower hazard of death in children diagnosed with cancer; brain tumor, leukemia, and sarcoma had higher hazard of mortality compared to leukemia. Children with a family history of cancer should be under regular follow-up. Treatment should be multidisciplinary and comprehensive. © 2018 Journal of Research in Medical Sciences |
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