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Immunogenetics of Lupus Erythematosus Publisher Pubmed



Unlu B1 ; Tursen U1 ; Jabalameli N2 ; Abdollahimajd F3 ; Rajabi F2, 4
Authors
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Authors Affiliations
  1. 1. Department of Dermatology, Mersin University, Mersin, Turkey
  2. 2. Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran

Source: Advances in Experimental Medicine and Biology Published:2022


Abstract

Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupus erythematosus (CLE) to severe disseminated disease in systemic lupus erythematosus (SLE). Lupus results from a complex interaction between genetic and epigenetic backgrounds and environmental triggers that cause loss of tolerance to self-antigens and the formation of autoantibodies. Genetic susceptibility plays a key role in the pathogenesis of lupus erythematosus. In most cases, multiple common alleles with modest effect sizes are combined to result in the polygenic inheritance of the disease but monogenic variants of lupus have also been described. Genes from the innate and adaptive immune system along with genes involved in apoptosis and immunoglobulin clearance have been linked to SLE. This chapter aims to explore the functions of these genes and their contribution to the pathogenesis of the disease. © 2022, Springer Nature Switzerland AG.
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