Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Immunotherapy for Breast Cancer Treatment Publisher Pubmed



Simonian M1 ; Ghaffari MH1 ; Negahdari B1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Biomedical Journal Published:2021


Abstract

Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel strategy in cancer treatment, has a potential in treating breast cancer patients. Although breast cancer has long been considered problematic to treat with immunotherapy, as it is immunologically cold, numerous newer preclinical and clinical reports now recommend that immunotherapy has the capability to treat breast cancer patients. In this review, we highlight the different immunotherapy strategies in breast cancer treatment. © 2021, Pasteur Institute of Iran. All rights reserved.
Related Docs
View other Related Docs
1. Adcs, As Novel Revolutionary Weapons for Providing a Step Forward in Targeted Therapy of Malignancies, Current Drug Delivery (2020)
2. Antibody-Drug Conjugates: Possibilities and Challenges, Avicenna Journal of Medical Biotechnology (2019)
3. Clinical Perspective: Antibody-Drug Conjugates for the Treatment of Her2-Positive Breast Cancer, Molecular Therapy (2023)
4. Chimeric Antigen Receptor T-Cell Therapy for Breast Cancer, Future Oncology (2021)
5. Novel Trastuzumab-Dm1 Conjugate: Synthesis and Bio-Evaluation, Journal of Cellular Physiology (2019)
6. Immunotherapeutic Approaches in Cancer, Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives (2018)
7. Recent Progress in Immunotherapy of Breast Cancer Targeting the Human Epidermal Growth Factor Receptor 2 (Her2), Journal of Oncology Pharmacy Practice (2021)
8. Immunotherapeutic Approaches in Cancer, Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives (2019)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (16)
Hamid Reza Mirzaei (5)
Other Related Docs
9. Approach to the Triple Negative Breast Cancer in New Drugs Area, International Journal of Hematology-Oncology and Stem Cell Research (2016)
10. The Current Landscape of Car T-Cell Therapy for Solid Tumors: Mechanisms, Research Progress, Challenges, and Counterstrategies, Frontiers in Immunology (2023)
11. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)
12. Breast Cancer Immunotherapy: Current and Novel Approaches, International Immunopharmacology (2021)
13. Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A Literature Review, Current Cancer Therapy Reviews (2024)
14. Tumor Immunology, Clinical Immunology (2022)
15. Immunotherapy of Cancers Comes of Age, Expert Review of Clinical Immunology (2017)
16. Cancer Immunotherapy Confers a Global Benefit, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2015)
17. Resistance to Immunotherapy in Human Malignancies: Mechanisms, Research Progresses, Challenges, and Opportunities, Journal of Cellular Physiology (2022)
18. Cancer Immunotherapy: Diverse Approaches and Obstacles, Current Pharmaceutical Design (2022)
19. Development and Biological Assessment of Mmae-Trastuzumab Antibody–Drug Conjugates (Adcs), Breast Cancer (2021)
20. Licensed Monoclonal Antibodies and Associated Challenges, Human Antibodies (2015)
21. Combination Therapy of Macromolecules and Small Molecules: Approaches, Advantages, and Limitations, Nanostructures for Cancer Therapy (2017)
22. Immunopathology and Immunotherapy for Breast Cancer, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
23. Long-Term Outcomes of Non-Metastatic Breast Cancer Patients by Molecular Subtypes, BMC Women's Health (2022)
24. Maldi-Ms: A Rapid and Reliable Method for Drug-To-Antibody Ratio Determination of Antibody-Drug Conjugates, Iranian Biomedical Journal (2019)
25. Genetically Modified Immune Cells Targeting Tumor Antigens, Pharmacology and Therapeutics (2020)
26. The Role of Her2 Alterations in Clinicopathological and Molecular Characteristics of Breast Cancer and Her2-Targeted Therapies: A Comprehensive Review, Medical Oncology (2022)
27. Monoclonal Antibodies for Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
28. Biomarkers for Predicting the Outcome of Various Cancer Immunotherapies, Critical Reviews in Oncology/Hematology (2021)
29. A Novel Anti-Her2 Bispecific Antibody With Potent Tumor Inhibitory Effects in Vitro and in Vivo, Frontiers in Immunology (2021)
30. Investigating the Relationship Between Types of Breast Tumors and Menopause in Women; [بررسی ارتباط انواع تومورهای پستان با یائسگی زنان], Tehran University Medical Journal (2023)
31. Monoclonal Antibody-Based Therapeutics, Targeting the Epidermal Growth Factor Receptor Family: From Herceptin to Pan Her, Journal of Pharmacy and Pharmacology (2018)
32. Pdl1 Positivity Rate Between Triple-Negative and Non-Luminal Her2+ Cases, Current Cancer Therapy Reviews (2022)
33. Evaluation of Exosomal Mir-9 and Mir-155 Targeting Pten and Dusp14 in Highly Metastatic Breast Cancer and Their Effect on Low Metastatic Cells, Journal of Cellular Biochemistry (2019)
34. Trastuzumab Deruxtecan Versus Trastuzumab Emtansine for Human Epidermal Growth Factor Receptor 2 Positive Metastatic Breast Cancer: Cost-Effectiveness Analysis From Iranian Experience, BMC Health Services Research (2025)
35. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
36. Predictive and Therapeutic Biomarkers in Chimeric Antigen Receptor T-Cell Therapy: A Clinical Perspective, Journal of Cellular Physiology (2019)
37. Car T Cell Therapy in Solid Tumors; With an Extensive Focus on Obstacles and Strategies to Overcome the Challenges, International Immunopharmacology (2021)
38. Combining Anti-Checkpoint Immunotherapies and Cancer Vaccines As a Novel Strategy in Oncological Therapy: A Review, Human Immunology (2025)
39. Cancer Immunotherapy Confers a Global Benefit, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
40. Cancer Immunology, Encyclopedia of Infection and Immunity (2022)
41. Understanding the Role of Integrins in Breast Cancer Invasion, Metastasis, Angiogenesis, and Drug Resistance, Oncogene (2021)
42. Personalized Medicine in Breast Cancer: Pharmacogenomics Approaches, Pharmacogenomics and Personalized Medicine (2019)
43. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
44. Antibody-Drug Therapeutic Conjugates: Potential of Antibody-Sirnas in Cancer Therapy, Journal of Cellular Physiology (2019)
45. Trastuzumab-Monomethyl Auristatin E Conjugate Exhibits Potent Cytotoxic Activity in Vitro Against Her2-Positive Human Breast Cancer, Journal of Cellular Physiology (2019)
46. Peptide and Protein Vaccines for Cancer, Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives (2019)
47. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 a Systematic Analysis for the Global Burden of Disease Study 2019, JAMA Oncology (2022)
48. The Tricks for Fighting Against Cancer Using Car Nk Cells: A Review, Molecular and Cellular Probes (2022)
49. Characterization of Immune Checkpoints Expression and Lymphocyte Densities of Iranian Breast Cancer Patients; the Co-Expression Status and Clinicopathological Associates, BMC Cancer (2023)
50. Isolation and Characterization of the Primary Epithelial Breast Cancer Cells and the Adjacent Normal Epithelial Cells From Iranian Women’S Breast Cancer Tumors, Cytotechnology (2018)