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The Emerging Microbiome-Based Approaches to Ibd Therapy: From Scfas to Urolithin A Publisher Pubmed



Rudiansyah M1 ; Abdalkareem Jasim S2 ; S Azizov B3 ; Samusenkov V4 ; Kamal Abdelbasset W5 ; Yasin G6 ; Mohammad HJ7 ; Jawad MA8 ; Mahmudiono T9 ; Hosseinifard SR10 ; Mirzaei R11 ; Karampoor S12
Authors
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Authors Affiliations
  1. 1. Division of Nephrology & Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin Hospital, Banjarmasin, Indonesia
  2. 2. Al-Maarif University College Medical Laboratory Techniques Department Al-Anbar-Ramadi, Ramadi, Iraq
  3. 3. Department of Therapeutic Disciplines No.1, Tashkent State Dental Institute, Tashkent, Uzbekistan
  4. 4. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  5. 5. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia
  6. 6. Department of Botany University of Bahauddin Zakariya University, Multan, Pakistan
  7. 7. Al-Manara College For Medical Sciences, Maysan, Iraq
  8. 8. Al-Nisour University College, Baghdad, Iraq
  9. 9. Department of Nutrition Faculty of Public Health Universitas, Airlangga, Indonesia
  10. 10. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  12. 12. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Digestive Diseases Published:2022


Abstract

Inflammatory bowel disease (IBD) is a group of chronic gastrointestinal inflammatory conditions which can be life-threatening, affecting both children and adults. Crohn's disease and ulcerative colitis are the two main forms of IBD. The pathogenesis of IBD is complex and involves genetic background, environmental factors, alteration in gut microbiota, aberrant immune responses (innate and adaptive), and their interactions, all of which provide clues to the identification of innovative diagnostic or prognostic biomarkers and the development of novel treatments. Gut microbiota provide significant benefits to its host, most notably via maintaining immunological homeostasis. Furthermore, changes in gut microbial populations may promote immunological dysregulation, resulting in autoimmune diseases, including IBD. Investigating the interaction between gut microbiota and immune system of the host may lead to a better understanding of the pathophysiology of IBD as well as the development of innovative immune- or microbe-based therapeutics. In this review we summarized the most recent findings on innovative therapeutics for IBD, including microbiome-based therapies such as fecal microbiota transplantation, probiotics, live biotherapeutic products, short-chain fatty acids, bile acids, and urolithin A. © 2022 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
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