Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids

Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids Publisher

Kouhzad M¹ ; Gotz F² ; Navidifar T³ ; Taki E⁴ ; Ghamari M⁵ ; Mohammadzadeh R⁶ ; Seyedolmohadesin M⁷ ; Bostanghadiri N⁸

Show Affiliations

1. Department of Genetics, Faculty of Science, Islamic Azad University North Tehran Branch, Tehran, Iran
2. Department of Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tubingen (IMIT), University of Tubingen, Tubingen, Germany
3. Department of Basic Sciences, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
4. Department of Microbiology, School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran
5. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Azad University, Tehran, Iran
8. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Oncology Published:2025

Abstract

Secondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects. The carcinogenic activities of SBAs include DNA damage, promotion of oxidative stress, and modulation of signaling pathways that drive tumorigenesis. Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. The article also discusses the complex interplay between SBAs and the host’s genetic and environmental factors, highlighting potential therapeutic implications and the need for targeted strategies to mitigate risks while harnessing beneficial effects. A comprehensive understanding of the delicate equilibrium between the deleterious and salutary impacts of SBAs has the potential to facilitate the development of innovative cancer prevention and treatment methodologies. Copyright © 2025 Kouhzad, Gotz, Navidifar, Taki, Ghamari, Mohammadzadeh, Seyedolmohadesin and Bostanghadiri.

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Style	Citing Format
MLA	Kouhzad M, et al.. "Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids." Frontiers in Oncology, vol. 15, no. , 2025, pp. -.
APA	Kouhzad M, Gotz F, Navidifar T, Taki E, Ghamari M, Mohammadzadeh R, Seyedolmohadesin M, Bostanghadiri N (2025). Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids. Frontiers in Oncology, 15(), -.
Chicago	Kouhzad M, Gotz F, Navidifar T, Taki E, Ghamari M, Mohammadzadeh R, Seyedolmohadesin M, Bostanghadiri N. "Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids." Frontiers in Oncology 15, no. (2025): -.
Harvard	Kouhzad M et al. (2025) 'Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids', Frontiers in Oncology, 15(), pp. -.
Vancouver	Kouhzad M, Gotz F, Navidifar T, Taki E, Ghamari M, Mohammadzadeh R, et al.. Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids. Frontiers in Oncology. 2025;15():-.
BibTex	@article{ author = {Kouhzad M and Gotz F and Navidifar T and Taki E and Ghamari M and Mohammadzadeh R and Seyedolmohadesin M and Bostanghadiri N}, title = {Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids}, journal = {Frontiers in Oncology}, volume = {15}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Kouhzad M AU - Gotz F AU - Navidifar T AU - Taki E AU - Ghamari M AU - Mohammadzadeh R AU - Seyedolmohadesin M AU - Bostanghadiri N TI - Carcinogenic and Anticancer Activities of Microbiota-Derived Secondary Bile Acids JO - Frontiers in Oncology VL - 15 IS - SP - EP - PY - 2025 ER -

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