Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Novel Strategies and Pharmaceutical Agents for the Treatment of Leish-Maniasis: A Review Publisher



Nilforoushzadeh MA1 ; Heidarikharaji M1 ; Zare M1 ; Torkamaniha E1 ; Rafati S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immuno-therapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran

Source: Anti-Infective Agents Published:2020


Abstract

Leishmaniasis is a major tropical disease. There is no effective vaccine against leish-maniasis and chemotherapy is still the most effective treatment for the disease. However, most of the common drugs have many disadvantages such as toxicity and high cost. Most important of all is the development of resistance against these drugs. Many studies have tried to provide new pharmaceutical agents and formulations in various ways to overcome these problems. In recent years, medical plants have been widely considered for leishmaniasis treatment. Besides, various drug delivery strategies have been studied for the treatment of leishmaniasis in order to increase activity and reduce the side effects of the drugs. Accordingly, nanotechnology will play an important role in the preparation of new pharmaceutical formulations. In this review, we focused on various therapeutic approaches for leishmaniasis. © 2020, Bentham Science Publishers. All rights reserved.
Related Docs
View other Related Docs
1. Iranian Native Plants on Treatment of Cutaneous Leishmaniosis: A Narrative Review, Iranian Journal of Parasitology (2017)
2. In Vitro and in Vivo Anti-Parasitic Activity of Biogenic Antimony Sulfide Nanoparticles on Leishmania Major (Mrho/Ir/75/Er), Parasitology Research (2019)
3. Niosomal Formulation of Amphotericin B Alone and in Combination With Glucantime: In Vitro and in Vivo Leishmanicidal Effects, Biomedicine and Pharmacotherapy (2019)
4. Sambucus Ebulus Extract Stimulates Cellular Responses in Cutaneous Leishmaniasis, Parasite Immunology (2019)
5. Effects of Amphotericin B-Conjugated Functionalized Carbon Nanoparticles in the Treatment of Cutaneous Leishmaniasis, Parasite Immunology (2024)
6. A Novel Strategy for Enhance Potentiation of Meglumine Antimoniate Against Leishmania Major in Vitro, Iranian Journal of Parasitology (2019)
7. Engineering the Niche for Hair Regeneration — a Critical Review, Nanomedicine: Nanotechnology# Biology# and Medicine (2019)
8. Biocompatibility and Nanostructured Materials: Applications in Nanomedicine, Artificial Cells# Nanomedicine and Biotechnology (2017)
Experts (# of related papers)
View all Related Experts
Mahdi Mohebali (7)
Mohammad Ali Nilforoushzadeh (2)
Other Related Docs
9. In Silico and in Vitro Comparative Activity of Green Tea Components Against Leishmania Infantum, Journal of Global Antimicrobial Resistance (2019)
10. The Therapeutic Effects of Olive Leaf Extract on Leishmania Major Infection in Balb/C Mice, Marmara Pharmaceutical Journal (2017)
11. Development of a Topical Liposomal Formulation of Amphotericin B for the Treatment of Cutaneous Leishmaniasis, International Journal for Parasitology: Drugs and Drug Resistance (2019)
12. In Vitro and In Vivo Susceptibility of Leishmania Major to Some Medicinal Plants, Asian Pacific Journal of Tropical Biomedicine (2017)
13. Effect of Peel and Leaf Extract of Walnut (Juglans Regia L.) on Cutaneous Leishmaniasis Caused by Leishmania Major in Balb/C Mice, Journal of Chemical and Pharmaceutical Sciences (2016)
14. Development of Nano-Carriers for Leishmania Vaccine Delivery, Expert Opinion on Drug Delivery (2020)
15. A Review Study About the Effect of Chitosan Nanocarrier on Improving the Efficacy of Amphotericin B in the Treatment of Leishmania From 2010 to 2020, Current Drug Delivery (2021)
16. Advances in Nanotechnology for Improving the Targeted Delivery and Activity of Amphotericin B (2011–2023): A Systematic Review, Nanotoxicology (2024)
17. Antileishmanial Activity of Allium Hirtifolium on Promastigote and Amastigote Developmental Stages of the Parasite, Leishmania Major, Medicinal Plants (2020)
18. Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination With Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis, Iranian Journal of Parasitology (2023)
19. History of Medical Parasitology and Parasitic Infections in Iran, Archives of Iranian Medicine (2016)
20. Development of Topical Liposomes Containing Miltefosine for the Treatment of Leishmania Major Infection in Susceptible Balb/C Mice, Acta Tropica (2019)