Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells

Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells Publisher Pubmed

Roudi R^{1, 2} ; Ebrahimi M³ ; Sabet MN² ; Najafi A⁴ ; Nourani MR⁵ ; Fomeshi MR³ ; Samadikuchaksaraei A^{6, 7} ; Shariftabrizi A⁸ ; Madjd Z^{1, 2}

Source: Future Oncology Published:2015

Abstract

Aims: The present study aimed to compare the gene-expression profiling of CD133+ and CD133- D10 cells. Materials & methods: Cancer stem cell-like properties and gene-expression profiling of CD133+ D10 cells versus CD133- cells were evaluated. Results: The CD133+ D10 cells showed significantly higher clonogenic and spheroid forming potential, also higher expression of stemness genes NANOG and OCT4A compared with the CD133- cells. Gene-expression profiling of CD133+ versus CD133- D10 cells revealed that 130 genes including ABC transporter superfamily (ABCC1, ABCG2 and ABCC6) were upregulated, while 61 genes including apoptosis modifying genes (CASP8 and TNFRSF4) were downregulated. Conclusion: We conclude that many genes involved in drug resistance and tumor aggressiveness are upregulated in CD133+ D10 cells and targeting them might be an efficient strategy for treatment of melanoma. © 2015 Future Medicine Ltd.

Related Docs

View other Related Docs

1. Expression of Cd133 Cancer Stem Cell Marker in Melanoma: A Systematic Review and Meta-Analysis, International Journal of Biological Markers (2016)

2. Cytoplasmic Expression of Cd133 Stemness Marker Is Associated With Tumor Aggressiveness in Clear Cell Renal Cell Carcinoma, Experimental and Molecular Pathology (2017)

3. Deciphering Biological Characteristics of Tumorigenic Subpopulations in Human Colorectal Cancer Reveals Cellular Plasticity, Journal of Research in Medical Sciences (2016)

Experts (# of related papers)

View all Related Experts

Vahid Haghpanah (1)

Hamid Reza Mirzaei (1)

Style	Citing Format
MLA	Roudi R, et al.. "Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells." Future Oncology, vol. 11, no. 17, 2015, pp. 2383-2393.
APA	Roudi R, Ebrahimi M, Sabet MN, Najafi A, Nourani MR, Fomeshi MR, Samadikuchaksaraei A, Shariftabrizi A, Madjd Z (2015). Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells. Future Oncology, 11(17), 2383-2393.
Chicago	Roudi R, Ebrahimi M, Sabet MN, Najafi A, Nourani MR, Fomeshi MR, Samadikuchaksaraei A, Shariftabrizi A, Madjd Z. "Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells." Future Oncology 11, no. 17 (2015): 2383-2393.
Harvard	Roudi R et al. (2015) 'Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells', Future Oncology, 11(17), pp. 2383-2393.
Vancouver	Roudi R, Ebrahimi M, Sabet MN, Najafi A, Nourani MR, Fomeshi MR, et al.. Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells. Future Oncology. 2015;11(17):2383-2393.
BibTex	@article{ author = {Roudi R and Ebrahimi M and Sabet MN and Najafi A and Nourani MR and Fomeshi MR and Samadikuchaksaraei A and Shariftabrizi A and Madjd Z}, title = {Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells}, journal = {Future Oncology}, volume = {11}, number = {17}, pages = {2383-2393}, year = {2015} }
RIS	TY - JOUR AU - Roudi R AU - Ebrahimi M AU - Sabet MN AU - Najafi A AU - Nourani MR AU - Fomeshi MR AU - Samadikuchaksaraei A AU - Shariftabrizi A AU - Madjd Z TI - Comparative Gene-Expression Profiling of Cd133+ and Cd133- D10 Melanoma Cells JO - Future Oncology VL - 11 IS - 17 SP - 2383 EP - 2393 PY - 2015 ER -

Science Communicator Platform

Authors

Abstract