Cell-Free Fetal Deoxyribonucleic Acid Results in Low-Risk Pregnancy Screenings for Aneuploidies Publisher



Shahbazian N¹ ; Barati M² ; Shojaei K³ ; Hoseininejad SS⁴ ; Dehghani AM⁵
Source: Journal of South Asian Federation of Obstetrics and Gynaecology Published:2018

Abstract

Introduction: Chromosomal aneuploidies are a common type of chromosomal defect that may impose heavy burdens on society and families. The most common chromosomal aneuploidies among the embryos are trisomies 21, 18, and 13. Prenatal screening and diagnosis are often used in prenatal care, and it seems to be a handy tool for doctors and women to make informed decisions about the continuation of pregnancies involved with genetic diseases. Prenatal noninvasive tests using cell-free fetal deoxyribonucleic acid (cff DNA) are a method for testing trisomy in embryos using the peripheral blood sample of the pregnant mother. Because most of the studies carried out on cff DNA have been in high-risk populations, this study attempted to examine the results of cff DNA in a population of low-risk aneuploidy pregnant women. Materials and methods: In this retrospective study, the study population was all pregnant women (n = 410), who underwent aneuploidy screening during the first or second trimester (with a low-risk result in quad test) in 2015–2016 and were at the risk of trisomies 13, 18, and 21 evaluated using cell-free fetal DNA test. Results: The mean age of pregnant women was 31.5 years, and 92.0% of the subjects were naturally pregnant, and only 8.1% had used assisted reproductive techniques (ART). Of these, 5.9% were fertilized by v fertilization (IVF) and 2.2% by IUI method. Results of cff DNA in all pregnant women were negative. Conclusion: According to the results of this study, cff DNA testing results in all low-risk pregnant women were negative, and it is not recommended as a routine test in pregnant women reported as a low-risk pregnancy in serum screening. © 2018, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved.