Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives

Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives Publisher

Azarkamanzad Z¹ ; Farzaneh F¹ ; Ghandi M² ; Feizabadi MM³ ; Jasemi S³

Show Affiliations

1. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Vanak, Tehran, 19938-91176, Iran
2. School of Chemistry, College of Science, University of Tehran, Tehran, 14155-6455, Iran
3. School of Medicine, Tehran University of Medical Sciences, Tehran, 19938-91176, Iran

Source: Russian Journal of Organic Chemistry Published:2022

Abstract

Abstract: Four pyranopyrimidinedione derivatives were prepared through a one-pot pseudo-three-component acetic acid-catalyzed reaction of 6-amino-1,3-dimethyluracil with 2-hydroxybenzaldehydes. The synthesized compounds were evaluated for their antibacterial activity against a panel of bacterial strains. The minimum inhibitory concentrations (MICs) were determined using broth microdilution assay according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. With the exception of 5-methoxy derivative, the other pyranopyrimidinediones exhibited antibacterial activities against all tested bacterial cultures. The most potent antibacterial effect was observed for 5-bromopyranopyrimidinedione derivative against clinical strains, which can be regarded as promising. © 2022, Pleiades Publishing, Ltd.

Style	Citing Format
MLA	Azarkamanzad Z, et al.. "Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives." Russian Journal of Organic Chemistry, vol. 58, no. 3, 2022, pp. 372-378.
APA	Azarkamanzad Z, Farzaneh F, Ghandi M, Feizabadi MM, Jasemi S (2022). Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives. Russian Journal of Organic Chemistry, 58(3), 372-378.
Chicago	Azarkamanzad Z, Farzaneh F, Ghandi M, Feizabadi MM, Jasemi S. "Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives." Russian Journal of Organic Chemistry 58, no. 3 (2022): 372-378.
Harvard	Azarkamanzad Z et al. (2022) 'Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives', Russian Journal of Organic Chemistry, 58(3), pp. 372-378.
Vancouver	Azarkamanzad Z, Farzaneh F, Ghandi M, Feizabadi MM, Jasemi S. Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives. Russian Journal of Organic Chemistry. 2022;58(3):372-378.
BibTex	@article{ author = {Azarkamanzad Z and Farzaneh F and Ghandi M and Feizabadi MM and Jasemi S}, title = {Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives}, journal = {Russian Journal of Organic Chemistry}, volume = {58}, number = {3}, pages = {372-378}, year = {2022} }
RIS	TY - JOUR AU - Azarkamanzad Z AU - Farzaneh F AU - Ghandi M AU - Feizabadi MM AU - Jasemi S TI - Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives JO - Russian Journal of Organic Chemistry VL - 58 IS - 3 SP - 372 EP - 378 PY - 2022 ER -

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