Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Human Herpesvirus-6 and Primary Brain Tumors: A Systematic Review and Meta-Analysis Publisher



Ghorbani S1 ; Letafati A2 ; Khatami A1 ; Farzi R3 ; Shabani S4 ; Moradi P5 ; Tambrchi V1 ; Saadati H6 ; Papizadeh S7 ; Rad MV8 ; Tabatabaei R9 ; Bahadory S10 ; Tavakoli A1, 11 ; Bokharaeisalim F1 Show All Authors
Authors
  1. Ghorbani S1
  2. Letafati A2
  3. Khatami A1
  4. Farzi R3
  5. Shabani S4
  6. Moradi P5
  7. Tambrchi V1
  8. Saadati H6
  9. Papizadeh S7
  10. Rad MV8
  11. Tabatabaei R9
  12. Bahadory S10
  13. Tavakoli A1, 11
  14. Bokharaeisalim F1
  15. Monavari SH1
  16. Fatemipour M1
  17. Hoseini M1
  18. Kiani SJ1
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  2. 2. Department of Virology, School of public health, Tehran University of Medical Science, Tehran, Iran
  3. 3. Department of Virology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran
  4. 4. Faculty of veterinary medicine, Azad University, Research Sciences Branch, Tehran, Iran
  5. 5. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  7. 7. Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Paramedicine Department, Islamic Azad University, Babol Medical Sciences Branch, Mazandaran, Babol, Iran
  9. 9. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  10. 10. Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  11. 11. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2022


Abstract

Aim: The present study aimed to find out the prevalence and any possible association between human herpesvirus (HHV-6) and primary brain tumors. Materials & methods: The systematic literature search was performed by finding related articles from major databases. Analysis was performed by comprehensive meta-analysis software. Results: A total of 13 (25 datasets) articles were included in the study, seven (15 datasets) of which were case/control and the rest (10 datasets) were cross-sectional studies. The pooled prevalence of HHV-6 among primary brain cancer patients was 29% (95% CI: 24-33%; I2 = 97.89%). An association was found between HHV-6 and primary brain cancer (summary odds ratio: 3.77% [95% CI: 2.59-5.49%; I2 = 19.0%]). Conclusion: Our analysis demonstrated that HHV-6 is associated with primary brain cancer. Reactivation of the virus could be triggered by the tumor, therefore, we cannot be certain that the virus appeared before the cancer development. © 2022 Future Medicine Ltd.
Related Docs
1. Association Between Human Epstein-Barr Virus and Brain Cancer: A Systematic Review and Meta-Analysis, Future Virology (2023)
2. Type Specific Real Time Pcr for Detection of Human Herpes Virus 6 in Schizophrenia and Bipolar Patients: A Case Control Study, BMC Psychiatry (2015)
3. Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis, Intervirology (2022)
4. Viral Infections and Risk of Thyroid Cancer: A Systematic Review and Empirical Bayesian Meta-Analysis, Pathology Research and Practice (2020)
5. A Systematic Review and Meta-Analysis to Evaluate Blood Levels of Interleukin-6 in Lung Cancer Patients, Kardiochirurgia i Torakochirurgia Polska (2023)
Experts (# of related papers)
View all Related Experts
Nazanin Zahra Shafiei Jandaghi (1)
Farhad Rezaei (1)