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Association Between Human Polyomavirus Infection and Brain Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Goudarzi Far F1 ; Tambrchi V2 ; Nahid Samiei R1 ; Nahid Samiei M3 ; Saadati H4 ; Moradi P5 ; Keyvanlou Z5 ; Advay S6 ; Nili M5 ; Abdi S7 ; Jamalvandi T8 ; Behzadpour M9 ; Kamalpour M10 ; Ebrahimdamavandi N11 Show All Authors
Authors
  1. Goudarzi Far F1
  2. Tambrchi V2
  3. Nahid Samiei R1
  4. Nahid Samiei M3
  5. Saadati H4
  6. Moradi P5
  7. Keyvanlou Z5
  8. Advay S6
  9. Nili M5
  10. Abdi S7
  11. Jamalvandi T8
  12. Behzadpour M9
  13. Kamalpour M10
  14. Ebrahimdamavandi N11
  15. Khatami A1
  16. Kiani SJ1
  17. Ghorbani S1
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  2. 2. Department of Microbiology, Golestan University of Medical Sciences, Golesatn, Iran
  3. 3. Shahrekord University of Medical Sciences, Cellular and Molecular Research Center, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  5. 5. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Virology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Animal Virology Department, Research and Diagnosis, Razi Vaccine and Serum Research Institute, Karaj, Iran
  8. 8. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Faculty of Medicine, Islamic Azad University, Tehran Medical Science Branch, Tehran, Iran
  10. 10. Khorramshahr University of Marine Sciences and Technology, School of Marine Science and Ocean, Iran
  11. 11. Department of Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Microbial Pathogenesis Published:2022


Abstract

Aim: The aim of this study was to investigate the prevalence and potential association between the infection with some members of the polyomaviridae family of viruses and development of the brain tumors. Methods: A systematic literature search was performed by finding relevant cross-sectional and case-control studies from a large online database. Heterogeneity, OR, and corresponding 95% CI were applied to all studies by meta-analysis and forest plots. The analysis was performed using Stata Software v.14. Results: Twenty-three articles (33 datasets) were included in the meta-analysis, four (four datasets) of which were case/control studies and the rest were cross-sectional. The pooled prevalence of polyomaviruses among brain cancer patients was 13% (95% CI: 8–20%; I2 = 96.91%). In subgroup analysis, the pooled prevalence of JCV, SV40, BKV and Merkel cell polyomavirus was 20%, 8%, 6%, and 16%, respectively. An association was found between polyomavirus infection and brain cancer [summary OR 7.22 (95% CI (2.36–22.05); I2 = 0%)]. The subgroup analysis, based on the virus type, demonstrated a strong association between JCV infection and brain cancer development [summary OR 10.34 (95% CI 1.10–97.42; I2 = 0%)]. Conclusion: The present study showed a significant association between polyomavirus infection and brain tumors. Moreover, these results suggest that polyomavirus infection may be a potential risk factor for the development of brain cancer. © 2022 Elsevier Ltd
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