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Association Between Human Epstein-Barr Virus and Brain Cancer: A Systematic Review and Meta-Analysis Publisher



Ghorbani S1, 2 ; Tambrchi V3 ; Farzi R4 ; Khatami A1 ; Samiei RN1 ; Saadati H5 ; Noori M6, 7 ; Letafati A8 ; Bahavar A3 ; Hezarpishe N9 ; Musavioun M10 ; Mirzaei B11 ; Meftagh MS12 ; Doust NK13 Show All Authors
Authors
  1. Ghorbani S1, 2
  2. Tambrchi V3
  3. Farzi R4
  4. Khatami A1
  5. Samiei RN1
  6. Saadati H5
  7. Noori M6, 7
  8. Letafati A8
  9. Bahavar A3
  10. Hezarpishe N9
  11. Musavioun M10
  12. Mirzaei B11
  13. Meftagh MS12
  14. Doust NK13
  15. Hejami F14
  16. Kiani SJ1
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Golestan University of Medical Sciences, Golesatn, Iran
  4. 4. Department of Virology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran
  5. 5. Department of Epidemiology & Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  6. 6. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Urology Research Center, Tehran University of Medical Science, Tehran, Iran
  8. 8. Department of Virology, School of Public Health, Tehran University of Medical Science, Tehran, Iran
  9. 9. Department of Genetics, School of Advance Sciences & Technology, Islamic Azad University, Tehran, Iran
  10. 10. Department of Cell & Molecular Biology, Faculty of Biological Sciences, Zand University, Shiraz, Iran
  11. 11. Faculty of Modern Science & Technology, Islamic Azad University, Tehran, Iran
  12. 12. Department of Biological Sciences, Islamic Azad University, Tehran, Iran
  13. 13. Department of Cellular & Molecular Biology, School of Genetic Engineering, Islamic Azad University, Zarghan, Fars, Iran
  14. 14. Islamic Azad University of Borujerd, Lorestan, Iran

Source: Future Virology Published:2023


Abstract

Aim: The aim of this study was to investigate the pooled prevalence and potential correlation between Epstein-Barr virus (EBV) infection and brain cancers. Materials & methods: We searched for relevant studies in main databases and analyzed the heterogeneity, odds ratio and corresponding 95% CI among all studies using STATA software V.14. Results: Fourteen articles were included in the meta-analysis. The pooled prevalence of EBV among brain cancer patients was 9% (95% CI: 3-16%; I2 = 91.06%). An association was found between EBV and brain cancer (OR: 6.90 [95% CI: 1.81-26.28]; I2 = 0%]). Conclusion: The results of this study indicate a significant association between EBV infection and brain cancer, suggesting EBV infection is a potential risk factor for brain cancer development. © 2023 Future Medicine Ltd.
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