Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
High-Density Lipoprotein-Cholesterol Functionality and Metabolic Syndrome: Protocol for Review and Meta-Analysis Publisher Pubmed



Roever L1 ; Resende ES1 ; Diniz ALD1 ; Penhasilva N1 ; Oconnell JL1 ; Gomes PFS1 ; Zanetti HR1, 2 ; Roerverborges AS2 ; Veloso FC1 ; De Souza FR1 ; Duarte PRA1 ; Fidale TM1 ; Casellafilho A3 ; Dourado PMM3 Show All Authors
Authors
  1. Roever L1
  2. Resende ES1
  3. Diniz ALD1
  4. Penhasilva N1
  5. Oconnell JL1
  6. Gomes PFS1
  7. Zanetti HR1, 2
  8. Roerverborges AS2
  9. Veloso FC1
  10. De Souza FR1
  11. Duarte PRA1
  12. Fidale TM1
  13. Casellafilho A3
  14. Dourado PMM3
  15. Chagas ACP3, 4
  16. Alihasanalsaegh S5
  17. Reis PEO6
  18. De Melo Costa Pinto R1
  19. Oliveira GBF7
  20. Avezum A7
  21. Neto M8
  22. Duraes AR8
  23. Da Silva RMFL9
  24. Grande AJ10
  25. Denardi C11
  26. Lopes RD12
  27. Nerlekar N13
  28. Alizadeh S14
  29. Hernandez AV15
  30. Da Rosa MI16
  31. Biondizoccai G17
Show Affiliations
Authors Affiliations
  1. 1. Federal University of Uberlandia, Department of Clinical Research, Heart Institute (InCor), Master Institute of Education President Antonio Carlos, IMEPAC, Uberlandia, Minas Gerais, Araguari, 38400-902, Brazil
  2. 2. Department of Clinical Research, HCFMUSP- University of Sao Paulo Medical School, Department of Cardiology, Sao Paulo, Brazil
  3. 3. Department of Cardiology, Faculty of Medicine ABC, Santo Andre, Brazil
  4. 4. Department of Cardiology, Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Department of Specialized and General Surgery, Fluminense Federal University, Rio de Janeiro, Brazil
  6. 6. Department of Clinical Research, Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil
  7. 7. Department of Health and Sciences, Graduate Program in Medicine and Health, Federal University of Bahia, Brazil
  8. 8. Department of Cardiology, Federal University of Minas Gerais MG, Brazil
  9. 9. Department of Medicine, Federal University of Mato Grosso MT, Brazil
  10. 10. Department of Clinical Research, FOP Unicamp, Sao Paulo, Brazil
  11. 11. Department of Clinical Research, Division of Cardiology, Duke University Medical Center, Durham, NC, United States
  12. 12. Department of Cardiology, Monash Cardiovascular Research Centre and MonashHeart, Clayton, VIC, Australia
  13. 13. Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  14. 14. Department of Comparative Effectiveness and Outcomes Research Health Outcomes, University of Connecticut, Hartford Hospital Evidence-Based Practice Center, Hartford, CT, United States
  15. 15. Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Brazil
  16. 16. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina, Italy
  17. 17. Department of Angiocardioneurology, IRCCS Neuromed Pozzilli, Italy

Source: Medicine (United States) Published:2018


Abstract

Introduction: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver. As one of the key functions of HDL, their hypothesis was that if they could measure HDL-C-efflux capacity, they would have a better handle on the role of HDL in atherosclerosis. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between HDL-C functionality and MetS. The aim of this study is to examine this association of HDL-C functionality with MetS in different ages and sex. Methods and analysis: The update systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (i.e., PubMed, EMBASE, Web of Science, and Google Scholar). Studies that examined the association between HDL-C functionality and MetS; focused on cohort, case-control, and cross-sectional studies; were conducted among in adults aged 40 to 70 years; provided sufficient data for calculating odds ratio or relative risk with a 95% confidence interval; were published as original articles written in English or other languages; and have been published until January 2018 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators. Ethics and dissemination: Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
Related Docs
1. Metabolic Syndrome and Risk of Stroke, Medicine (United States) (2018)
2. Epicardial Adipose Tissue and Metabolic Syndrome: An Update Protocol for Systematic Review and Meta-Analysis, Medicine (United States) (2018)
3. Epicardial Adipose Tissue and Carotid Artery Disease, Medicine (United States) (2018)