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Encapsulation of Stem Cells Publisher



Khanmohammadi M1, 2 ; Namini MS3 ; Bagher Z4, 5 ; Hosseini M6 ; Ahmadkhani N6 ; Khosrowpour Z5 ; Nahanmoghadam A7 ; Ebrahimibarough S3
Authors
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Authors Affiliations
  1. 1. Skull Base Research Center, The Five Senses Institute, Hazrat Rasoul Akram Hospital, School of Medicine, Iran
  2. 2. University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. ENT and Head & Neck Research Center and Department, The Five Senses Institute, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  5. 5. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  6. 6. School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, United States
  7. 7. Department of Chemical Engineering, Faculty of Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran

Source: Principles of Biomaterials Encapsulation: Volume 2 Published:2023


Abstract

Stem cells (SCs), as potent therapeutic tools to treat various regenerative diseases, are characterized by their self-renewal and capacity to differentiate into specific cell types under defined microenvironments. Today, SC encapsulation represents a novel technique utilized to shield SCs inside semipermeable and biocompatible materials. Creating three-dimensional (3D) microenvironments in encapsulation systems helps to protect SCs from the host’s immune system, maintain self-renewal potency, improve cell proliferation, induce SC differentiation, and, by allowing the diffusion of oxygen, growth factors, and cytokines, increase the viability of cells. This chapter will provide an overview of the application of encapsulation technology for maintaining SC potency, increasing cell viability, directing SC differentiation, and investigating production methods. Finally we focus on application of SCs encapsulation technology for tissue regeneration in various disorders. © 2023 Elsevier Ltd. All rights reserved.
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