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Synthesis and Characterisation of Highly Interconnected Porous Poly(Ε-Caprolactone)-Collagen Scaffolds: A Therapeutic Design to Facilitate Tendon Regeneration Publisher



Mozafari M1 ; Kargozar S2 ; De Santiago GT3, 4, 5 ; Mohammadi MR6 ; Milan PB7, 8 ; Foroutan Koudehi M9 ; Aghabarari B10 ; Nourani MR9
Authors
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Authors Affiliations
  1. 1. Bioengineering Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran
  2. 2. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, MA, United States
  4. 4. Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology and Microsystems Technologies Laboratories, Massachusetts Institute of Technology, Cambridge, MA, United States
  5. 5. Centro de Biotecnologia-FEMSA, Tecnologico de Monterrey at Monterrey, Monterrey, Mexico
  6. 6. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA, United States
  7. 7. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Faculty of Advanced Technologies in Medicine, Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Tissue Engineering and Regenerative Medicine, Nano Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  10. 10. Nanomaterials Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran

Source: Materials Technology Published:2018


Abstract

Current tissue-engineering approaches require improved biomaterials to balance microstructural and mechanical design criteria. We investigated the effect of adding a naturally occurring polymer, collagen, to a synthetic scaffold made of poly(ε-caprolactone) (PCL). Hybrid PCL-collagen scaffolds with different collagen concentrations were prepared by solvent casting and freeze-drying techniques that included a subsequent chemical cross-linking. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to characterise the microstructure and chemical interactions of the scaffolds. We found that the porous structure of the scaffolds can be tailored by changing the collagen concentration. In addition, we concluded that the scaffolds with 40% collagen exhibit remarkable enhancement in physicochemical and biological characteristics for tendon regeneration. The regenerated tissues were oriented longitudinally in relation to the long axis of the natural tendon, with a substantial number of blood vessels appearing deep within the scaffolds. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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