Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies

Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies Publisher

Ghorghi M¹ ; Rafienia M² ; Nasirian V³ ; Bitaraf FS⁴ ; Gharravi AM⁵ ; Zarrabi A⁶

Show Affiliations

1. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Biosensor Research Center, Department of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran
3. Department of Biological Sciences, Louisiana State University in Shreveport, Shreveport, LA, United States
4. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
5. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
6. SUNUM, Nanotechnology Research and Application Center, Sabanci University, Istanbul, Turkey

Source: Polymers for Advanced Technologies Published:2020

Abstract

Electrospinning as an effective and accessible method is known to yield scaffolds with desired physical, chemical, and biological properties for tissue engineering. In the present study, captopril (CP)-loaded polycaprolactone (PCL)/carbon quantum dots (CQDs) nanocomposite scaffolds were fabricated for bone tissue regeneration. The microstructure and hydrophilicity/hydrophobicity ratio of scaffolds were assessed by scanning electron microscopy and wettability test, respectively. The results showed that the presence of CQDs and CP in the scaffolds decreased the fiber diameter (1180 ± 281.5-345 ± 110 nm) and also it led to an increase in the surface hydrophilicity (137°-0°) of scaffolds. Evaluation of the scaffolds' functional groups was performed using Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy. The ultimate tensile strength of scaffolds was in the range of 6.86 ± 0.00 to 22.09 ± 0.06 MPa. Distribution of CQDs in the scaffolds' fibers was investigated by transmission electron microscopy and fluorescent spectrometer. The cell viability, attachment, proliferation, and alkaline phosphatase (ALP) activity of scaffolds were assessed in vitro. Based on the overall results, the scaffold containing CQDs and CP led to a significant increase in the cells' proliferation and ALP activity. Therefore, the PCL/CQDs/CP is recommended as a potential nanocomposite scaffold for bone tissue regeneration. © 2020 John Wiley & Sons Ltd

2. On the Bioactivity and Mechanical Properties of Gehlenite Nanobioceramic: A Comparative Study, Journal of Medical Signals and Sensors (2020)

3. Nanostructures for Prevention, Diagnosis, and Treatment of Viral Respiratory Infections: From Influenza Virus to Sars-Cov-2 Variants, Journal of Nanobiotechnology (2023)

4. Synthesis, Properties and Biomedical Applications of Carbon-Based Quantum Dots: An Updated Review, Biomedicine and Pharmacotherapy (2017)

Experts (# of related papers)

Babak Negahdari (1)

Ali Etemadi (1)

Style	Citing Format
MLA	Ghorghi M, et al.. "Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies." Polymers for Advanced Technologies, vol. 31, no. 12, 2020, pp. 3302-3315.
APA	Ghorghi M, Rafienia M, Nasirian V, Bitaraf FS, Gharravi AM, Zarrabi A (2020). Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies. Polymers for Advanced Technologies, 31(12), 3302-3315.
Chicago	Ghorghi M, Rafienia M, Nasirian V, Bitaraf FS, Gharravi AM, Zarrabi A. "Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies." Polymers for Advanced Technologies 31, no. 12 (2020): 3302-3315.
Harvard	Ghorghi M et al. (2020) 'Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies', Polymers for Advanced Technologies, 31(12), pp. 3302-3315.
Vancouver	Ghorghi M, Rafienia M, Nasirian V, Bitaraf FS, Gharravi AM, Zarrabi A. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies. Polymers for Advanced Technologies. 2020;31(12):3302-3315.
BibTex	@article{ author = {Ghorghi M and Rafienia M and Nasirian V and Bitaraf FS and Gharravi AM and Zarrabi A}, title = {Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies}, journal = {Polymers for Advanced Technologies}, volume = {31}, number = {12}, pages = {3302-3315}, year = {2020} }
RIS	TY - JOUR AU - Ghorghi M AU - Rafienia M AU - Nasirian V AU - Bitaraf FS AU - Gharravi AM AU - Zarrabi A TI - Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies JO - Polymers for Advanced Technologies VL - 31 IS - 12 SP - 3302 EP - 3315 PY - 2020 ER -

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