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Comparative Study of Different Polymeric Coatings for the Next-Generation Magnesium-Based Biodegradable Stents Publisher Pubmed



Ahmadi Lakalayeh G1 ; Rahvar M1 ; Haririan E2 ; Karimi R3 ; Ghanbari H1, 2, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Regenerative Nanomedicine Research Group, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2018


Abstract

Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility. Potentiodynamic and electrochemical impedance spectroscopy results demonstrated that PLA and PLGA coating performed better in improving corrosion resistance in comparison with uncoated and other coated samples. Although all coated and bare samples displayed desirable results of haemocompatibility assays, PLA-coated samples showed better outcome in terms of biocompatibility. The results revealed that PLA can be considered as a potential coating material to enhance the main characteristics of magnesium-based bioabsorbable stents. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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