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The Potential Role of Circular Rnas in Regulating P53 in Different Types of Cancers Publisher Pubmed



Farhadi E1, 2 ; Khomeijanifarahani M1, 3 ; Nikbakhsh R1, 4 ; Azizan A1, 2 ; Soltani S1 ; Barekati H5 ; Mahmoudi M1, 2
Authors
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Authors Affiliations
  1. 1. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  5. 5. School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2024


Abstract

P53 tumor suppressor is a major regulator of various cellular processes and functions. It has been reported that mutation or inactivation of p53 plays a crucial role in tumorigenesis in different types of cancers. Circular RNAs (circRNAs) are single-stranded non-coding RNAs that have significant post-transcriptional effects on the regulation of gene expression in various ways. These molecules can alter the expression and function of multiple genes and proteins. In the present study, we aimed to review circRNAs that regulate the expression, function, and stability of p53 and the possible interactions between these molecules and p53. Considering the importance of p53 in cancer and the network between p53 and circRNAs, future clinical trials targeting these circRNAs as therapeutic agents deserve worthy of attention. © 2024
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