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Circ_0067934 As a Novel Therapeutic Target in Cancer: From Mechanistic to Clinical Perspectives Publisher Pubmed



Alhawary SIS1 ; Asghar W2 ; Amin A3 ; Mustafa YF4 ; Hjazi A5 ; Almulla AF6 ; Ali SAJ7 ; Ali SS8 ; Romeroparra RM9 ; Abdulhussien Alazbjee AA10 ; Mahmoudi R11 ; Fard SRH12
Authors
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Authors Affiliations
  1. 1. Department of Business Administration, Business School, Al al-Bayt University, P.O.BOX 130040, Mafraq, 25113, Jordan
  2. 2. MBBS, Rai Medical College Sargodha, Pakistan
  3. 3. Quaid e Azam Medical College, Bahawal Victorial Hospital, Bahawalpur, Pakistan
  4. 4. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
  5. 5. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  6. 6. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  7. 7. Pharmacy Department, Al-Safwa University College, Karbalaa, Iraq
  8. 8. College of Dentistry, Al-Bayan University, Baghdad, Iraq
  9. 9. Universidad Continental, Lima, Peru
  10. 10. Collage of Medicine, Al-Ayen University, Thi-Qar, Iraq
  11. 11. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Circular RNAs, as a type of non-coding RNAs, are identified in a various cell. Circular RNAs have stable structures, conserved sequence, and tissue and cell-specific level. High throughput technologies have proposed that circular RNAs act via various mechanisms like sponging microRNAs and proteins, regulating transcription factors, and scaffolding mediators. Cancer is one of the major threat for human health. Emerging data have proposed that circular RNAs are dysregulated in cancers as well as are associated with aggressive behaviors of cancer –related behaviors like cell cycle, proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT). Among them, circ_0067934 was shown to act as an oncogene in cancers to enhance migration, invasion, proliferation, cell cycle, EMT, and inhibit cell apoptosis. In addition, these studies have proposed that it could be a promising diagnostic and prognostic biomarker in cancer. This study aimed to review the expression and molecular mechanism of circ_0067934 in modulating the malignant behaviors of cancers as well as to explore its potential as a target in cancer chemotherapy, diagnosis, prognosis and treatment. © 2023 Elsevier GmbH
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