A Comprehensive Review on the Role of Non-Coding Rnas in the Pathophysiology of Bipolar Disorder Publisher Pubmed



Ghafourifard S¹ ; Badrlou E¹ ; Taheri M² ; Dursteler KM^{3, 4} ; Bruhl AB⁵ ; Sadeghibahmani D^{5, 6, 7} ; Brand S^{5, 6, 8, 9}
Source: International Journal of Molecular Sciences Published:2021

Abstract

Aim: Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder. Results: Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation. Conclusion: Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.