Tehran University of Medical Sciences

Science Communicator Platform

Share By
Enhancing in Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Via Sustained Dexamethasone Delivery in 3D-Printed Hybrid Scaffolds Based on Polycaprolactone-Nanohydroxyapatite/Alginate-Gelatin for Bone Regeneration Publisher

Summary: Can 3D-printed scaffolds heal bones? Study finds PCL-nHA, Alg-Gel boost osteogenic differentiation. #BoneRepair #3DPrinting

Noory P1 ; Farmani AR2 ; Ai J1 ; Bahrami N1, 3 ; Bayat M3 ; Ebrahimibarough S1 ; Farzin A4 ; Shojaie S5 ; Hajmoradi H6 ; Mohamadnia A7, 8 ; Goodarzi A2
Authors

Source: Journal of Biological Engineering Published:2025


Abstract

Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel). 3D-printing scaffolds were used to control the delivery of dexamethasone (DEX) to enhance bone repair. DEX-loaded scaffolds promoted osteogenic differentiation and mineralization of human endometrial mesenchymal stem cells (hEnMSCs). © The Author(s) 2025.
Related Docs
View other Related Docs
1. Exosome-Functionalized Collagen-Coated 3D-Printed Pcl Scaffold for Enhanced Osteogenic Differentiation and Bone Regeneration: An in Vitro and in Vivo Study, Journal of Biological Engineering (2025)
2. 3D Printed Hetero-Layered Composite Scaffold With Engineered Superficial Zone Promotes Osteogenic Differentiation of Pre-Osteoblast Mc3t3-E1 Cells, Surfaces and Interfaces (2024)
3. Regeneration of Bone Tissue Using Nanofibers Made From Electrospun Polycaprolactone (Pcl) and a Hydrogel Composed of Alginate (Alg/Pcl), Regenerative Engineering and Translational Medicine (2025)
Experts (# of related papers)
View all Related Experts
Mahmoud Azami (5)
Somayeh Ebrahimi Barough (2)
Enhancing in Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Via Sustained Dexamethasone Delivery in 3D-Printed Hybrid Scaffolds Based on Polycaprolactone-Nanohydroxyapatite/Alginate-Gelatin for Bone Regeneration
Other Related Docs
4. A Critical Review on the 3D Bioprinting in Large Bone Defects Regeneration, Bioprinting (2024)
5. Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Using 3D-Printed Pdlla/ Β-Tcp Nanocomposite Scaffolds, Bioprinting (2021)
6. Fabrication and Characterization of 3D Collagen/ Polycaprolactone/ Hydroxyapatite Nanoparticles Scaffold Using 3D Printing Method for Repairing Damaged Bone Tissue, International Journal of Engineering, Transactions B: Applications (2025)
7. Recent Approaches to Enhance Osteogenesis of Dental Pulp Stem Cells on Electrospun Scaffolds, Current Stem Cell Research and Therapy (2024)
8. 3D-Bioprinted Dual-Crosslinked Oxidized Gellan Gum-Decellularized Human Amniotic Membrane Hydrogels Reinforced With Aminolyzed Electrospun Nanofibers for Cartilage Regeneration, Biomaterials Advances (2026)
9. 3D Printing of Complicated Gelma-Coated Alginate/Tri-Calcium Silicate Scaffold for Accelerated Bone Regeneration, International Journal of Biological Macromolecules (2023)
10. Development of Extrusion-Based 3D-Printed Chitosan/Magnesium-Doped Nanohydroxyapatite Scaffolds Functionalized With Icariin, Lithium Chloride and Naringin for Enhanced Bone Regeneration in Vitro and in Vivo, International Journal of Biological Macromolecules (2026)
11. Scrophularia Striata Extract Incorporated Nanofibrous Scaffold Improved Osteogenic Differentiation of Mesenchymal Stem Cells, Journal of Drug Delivery Science and Technology (2023)
12. Development of Osteon-Like Scaffold-Cell Construct by Quadruple Coaxial Extrusion-Based 3D Bioprinting of Nanocomposite Hydrogel, Biomaterials Advances (2023)
13. Clinical Advances in Calcium Phosphate for Maxillomandibular Bone Regeneration: From Bench to Bedside, Ceramics (2025)
14. Chitosan/Hydroxyapatite Hydrogels for Localized Drug Delivery and Tissue Engineering: A Review, Carbohydrate Polymer Technologies and Applications (2025)
15. Recent Advances on 3D-Printed Pcl-Based Composite Scaffolds for Bone Tissue Engineering, Frontiers in Bioengineering and Biotechnology (2023)
16. In Vitro Evaluation of Human Endometrial Stem Cell-Derived Osteoblast-Like Cells’ Behavior on Gelatin/Collagen/Bioglass Nanofibers’ Scaffolds, Journal of Biomedical Materials Research - Part A (2016)
17. Biological Study of Polyethyleneimine Functionalized Polycaprolactone 3D-Printed Scaffolds for Bone Tissue Engineering, Journal of Applied Polymer Science (2022)
18. Kaempferol-Loaded Bioactive Glass-Based Scaffold for Bone Tissue Engineering: In Vitro and in Vivo Evaluation, Scientific Reports (2023)
19. Challenges in Three-Dimensional Printing of Bone Substitutes, Tissue Engineering - Part B: Reviews (2019)
20. Robocast Zn- and Co-Doped Bioactive Glass/Tricalcium Phosphate Scaffolds for Bone Regeneration, Journal of Biological Engineering (2026)