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Recent Approaches to Enhance Osteogenesis of Dental Pulp Stem Cells on Electrospun Scaffolds Publisher Pubmed



Safari Z1 ; Aghili SS2 ; Hassantash S1 ; Iranmanesh E3 ; Abouali M4 ; Bagherianlemraski M5 ; Ghasemzadeh S6 ; Dadgar E7 ; Barati G8 ; Saburi E9
Authors
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Authors Affiliations
  1. 1. Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Faculty of Dentistry, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran
  5. 5. School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
  7. 7. Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Stem Cell Technology Research Center, Tehran, Iran
  9. 9. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Current Stem Cell Research and Therapy Published:2024


Abstract

Critical-sized bone defects are a challenging issue during bone regeneration. Bone tissue engineering is aimed to repair such defects using biomimicking scaffolds and stem cells. Electrospinning allows the fabrication of biocompatible, biodegradable, and strengthened scaffolds for bone regeneration. Natural and synthetic polymers, alone or in combination, have been employed to fabricate scaffolds with appropriate properties for the osteogenic differentiation of stem cells. Dental pulps are rich in stem cells, and dental pulp stem cells (DPSCs) have a high capacity for proliferation, differentiation, immunomodulation, and trophic factor expression. Researchers have tried to enhance osteogenesis through scaffold modification approaches, including incorporation or coating with mineral, inorganic materials, and herbal extract components. Among them, the incorporation of nanofibers with hyaluronic acid (HA) has been widely used to promote osteogenesis. In this review, the electrospun scaffolds and their modifications used in combination with DPSCs for bone regeneration are discussed. © 2024 Bentham Science Publishers.
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