Can Berberine Serve As a New Therapy for Parkinson’S Disease? Publisher Pubmed



Dadgostar E^{1, 2} ; Moghanlou M³ ; Parvaresh M⁴ ; Mohammadi S⁵ ; Khandan M⁶ ; Aschner M⁷ ; Mirzaei H⁸ ; Tamtaji OR^{9, 10}
Source: Neurotoxicity Research Published:2022

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration and deposition of alpha-synuclein. Mechanisms associated with PD etiology include oxidative stress, apoptosis, autophagy, and abnormalities in neurotransmission, to name a few. Drugs used to treat PD have shown significant limitations in their efficacy. Therefore, recent focus has been placed on the potential of active plant ingredients as alternative, complementary, and efficient treatments. Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease. Here, we review contemporary knowledge supporting the need to further characterize berberine as a potential treatment for PD. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.