Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus

Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus Publisher Pubmed

Zargari Samani O¹ ; Mahmoodnia L² ; Izad M³ ; Shirzad H¹ ; Jamshidian A¹ ; Ghatrehsamani M¹ ; Kheiri S⁴ ; Sadeghian L¹ ; Soltani A¹ ; Sarmadi A¹

Show Affiliations

1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
3. Immunology Department, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
4. Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Kaohsiung Journal of Medical Sciences Published:2018

Abstract

Type 1 diabetes is a multi-factorial disease that can develop due to the combination of genetic and environmental factors. Viruses, particularly enteroviruses, are major environmental candidates in the pathogenesis of type 1 diabetes, even though the mechanisms of pathogenicity of these viruses and their effects on the immune system have not been understood very well yet. Previous studies show that any imbalance in the population of different lymphocyte subsets could develop autoimmune diseases. Our theory is that enteroviral infection causes an impairment in the distribution of lymphocyte subtypes and consequently results in the diabetes onset in some individuals. Therefore, in this project, we evaluated the distribution of T CD8+ lymphocytes and their subsets in type 1 diabetes patients. This study was conducted to investigate the relationship between enteroviral infection and type 1 diabetes mellitus in an Iranian population, and suggestion a predicting approach for susceptible subjects. © 2018

Style	Citing Format
MLA	Zargari Samani O, et al.. "Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus." Kaohsiung Journal of Medical Sciences, vol. 34, no. 5, 2018, pp. 274-280.
APA	Zargari Samani O, Mahmoodnia L, Izad M, Shirzad H, Jamshidian A, Ghatrehsamani M, Kheiri S, Sadeghian L, Soltani A, Sarmadi A (2018). Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus. Kaohsiung Journal of Medical Sciences, 34(5), 274-280.
Chicago	Zargari Samani O, Mahmoodnia L, Izad M, Shirzad H, Jamshidian A, Ghatrehsamani M, Kheiri S, Sadeghian L, Soltani A, Sarmadi A. "Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus." Kaohsiung Journal of Medical Sciences 34, no. 5 (2018): 274-280.
Harvard	Zargari Samani O et al. (2018) 'Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus', Kaohsiung Journal of Medical Sciences, 34(5), pp. 274-280.
Vancouver	Zargari Samani O, Mahmoodnia L, Izad M, Shirzad H, Jamshidian A, Ghatrehsamani M, et al.. Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus. Kaohsiung Journal of Medical Sciences. 2018;34(5):274-280.
BibTex	@article{ author = {Zargari Samani O and Mahmoodnia L and Izad M and Shirzad H and Jamshidian A and Ghatrehsamani M and Kheiri S and Sadeghian L and Soltani A and Sarmadi A}, title = {Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus}, journal = {Kaohsiung Journal of Medical Sciences}, volume = {34}, number = {5}, pages = {274-280}, year = {2018} }
RIS	TY - JOUR AU - Zargari Samani O AU - Mahmoodnia L AU - Izad M AU - Shirzad H AU - Jamshidian A AU - Ghatrehsamani M AU - Kheiri S AU - Sadeghian L AU - Soltani A AU - Sarmadi A TI - Alteration in Cd8+ T Cell Subsets in Enterovirus-Infected Patients: An Alarming Factor for Type 1 Diabetes Mellitus JO - Kaohsiung Journal of Medical Sciences VL - 34 IS - 5 SP - 274 EP - 280 PY - 2018 ER -

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