The Impact of Probiotic and Synbiotic Supplementation on Oxidative Stress and Inflammation Publisher



H Sharma HIMANSHU ; S Kumar SANJESH ; Sim Ashique Sumel IMOHAMMED ; P Bhowmick PRATIBHA ; R Pal RADHESHYAM ; A Farid ARSHAD ; R Javed ROOMAH ; F Taghizadehhesary FARZAD ; S Mandal SUBHAJIT
Source: Published:2024

Abstract

The ecosystem known as the gut microbiota is essential to the organism’s regular operation. It is composed of numerous non-pathogenic symbiotic bacteria which are present in the distal portion of the human gut. Numerous acute or chronic dysfunctional processes in the host are directly linked to dysbiosis, or an imbalance in the gut microbiota. Consequently, the capability to alter the gut microbiota is increasingly being acknowledged as a potential therapeutic approach for several ailments. An imbalance between the body’s production of reactive oxygen species (ROS) leads to oxidative stress and its capacity to remove them through antioxidants. Certain probiotic strains found in synbiotics can produce antioxidants, scavenge ROS, and reduce oxidative stress. Moreover, the prebiotic components of synbiotic could encourage the development of healthy gut flora, potentially enhancing the gut’s ability to produce and absorb antioxidants. Because they change the gut microbiota and improve the gut’s environment, synbiotics may help lower inflammation and oxidative stress. Further research is required to completely understand the specific processes and the range of situations in which they might be beneficial. © 2024 Elsevier B.V., All rights reserved.