Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives

Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives Publisher

Akbari M¹ ; Maleki A² ; Bahadorikhalili S³ ; Taayoshi F¹ ; Adibpour N¹ ; Mahdavi M³

Show Affiliations

1. Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
3. Endocrinology and Metabolism Clinical Sciences Institute, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Chinese Chemical Society Published:2021

Abstract

An efficient method is applied for the synthesis of novel 2-(2-chloroquinolin-3-yl)-N-alkylimidazo[1,2-a]pyridin-3-amine derivatives. The method is based on a two-step approach from acetanilide, 2-chloro-3-formyl quinoline, 2-aminopyridine, and isocyanide under mild reaction conditions. In the first step, acetanilide forms 2-chloroquinoline-3-carbaldehyde in the presence of phosphoryl chloride. The synthesized 2-chloroquinoline-3-carbaldehyde takes part in a multicomponent reaction with 2-aminopyridine, and isocyanide in the presence of trimethylsilyl chloride. The reaction is facile and the products are synthesized in high isolated yields under mild reaction conditions. © 2021 The Chemical Society Located in Taipei & Wiley-VCH GmbH

Style	Citing Format
MLA	Akbari M, et al.. "Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives." Journal of the Chinese Chemical Society, vol. 68, no. 7, 2021, pp. 1328-1333.
APA	Akbari M, Maleki A, Bahadorikhalili S, Taayoshi F, Adibpour N, Mahdavi M (2021). Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives. Journal of the Chinese Chemical Society, 68(7), 1328-1333.
Chicago	Akbari M, Maleki A, Bahadorikhalili S, Taayoshi F, Adibpour N, Mahdavi M. "Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives." Journal of the Chinese Chemical Society 68, no. 7 (2021): 1328-1333.
Harvard	Akbari M et al. (2021) 'Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives', Journal of the Chinese Chemical Society, 68(7), pp. 1328-1333.
Vancouver	Akbari M, Maleki A, Bahadorikhalili S, Taayoshi F, Adibpour N, Mahdavi M. Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives. Journal of the Chinese Chemical Society. 2021;68(7):1328-1333.
BibTex	@article{ author = {Akbari M and Maleki A and Bahadorikhalili S and Taayoshi F and Adibpour N and Mahdavi M}, title = {Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives}, journal = {Journal of the Chinese Chemical Society}, volume = {68}, number = {7}, pages = {1328-1333}, year = {2021} }
RIS	TY - JOUR AU - Akbari M AU - Maleki A AU - Bahadorikhalili S AU - Taayoshi F AU - Adibpour N AU - Mahdavi M TI - Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives JO - Journal of the Chinese Chemical Society VL - 68 IS - 7 SP - 1328 EP - 1333 PY - 2021 ER -

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