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Polymorphisms in Egfr and Il28b Are Associated With Spontaneous Clearance in an Hcv-Infected Iranian Population Publisher Pubmed



Carapito R1 ; Poustchi H2 ; Kwemou M1 ; Untrau M1 ; Sharifi AH2 ; Merat S2, 3 ; Hajsheykholeslami A2 ; Jabbari H2 ; Esmaili S2 ; Michel S1 ; Toussaint J1 ; Le Gentil M1 ; Ansarimoghaddam A4 ; Radosavljevic M1 Show All Authors
Authors
  1. Carapito R1
  2. Poustchi H2
  3. Kwemou M1
  4. Untrau M1
  5. Sharifi AH2
  6. Merat S2, 3
  7. Hajsheykholeslami A2
  8. Jabbari H2
  9. Esmaili S2
  10. Michel S1
  11. Toussaint J1
  12. Le Gentil M1
  13. Ansarimoghaddam A4
  14. Radosavljevic M1
  15. Etemadi A2, 5
  16. Georgel P1
  17. Malekzadeh R2, 3
  18. Bahram S1
Show Affiliations
Authors Affiliations
  1. 1. Plateforme GENOMAX, Laboratoire D'ImmunoRhumatologie Moleculaire, INSERM UMR-S1109, LabEx Transplantex, Centre de Recherche D'Immunologie et D'Hematologie, Faculte de Medecine, Federation Hospitalo-Universitaire (FHU) OMICARE, Federation de Medecine Translationnelle de Strasbourg (FMTS), Universite de Strasbourg, 4 rue Kirschleger, Strasbourg Cedex, 67085, France
  2. 2. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences Shariati Hospital, Kargar Shomali Avenue, Tehran, 14117, Iran
  3. 3. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences Shariati Hospital, Tehran, Iran
  4. 4. Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, Iran
  5. 5. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States

Source: Genes and Immunity Published:2015


Abstract

Although most hepatitis C virus (HCV)-infected individuals develop chronic infection, about 25% of them are able to clear the virus spontaneously without any therapeutic intervention. The aim of the present study was to identify genes associated with spontaneous HCV clearance in a population of Iranian patients. We genotyped 110 single-nucleotide polymorphisms (SNPs) in 59 selected-candidate-genes in a cohort of 107 HCV-infected participants who spontaneously cleared the infection and 176 participants whose infection persisted. Three out of the 110 SNPs were found to be associated with HCV outcome (P-valueso0.03). rs11506105 in EGFR (epidermal growth factor receptor gene), and rs11881222 and rs12979860 in IL28B (interferon-λ3 gene). Multivariate logistic regression of the three markers showed that the A/A genotypes in both rs11506105 (EFGR) and rs11881222 (IL28B), and the C/C genotype in rs12979860 (IL28B) are associated with HCV clearance (recessive model: odds ratio (OR) = 2.06, 95% confidence interval (95% CI) = 1.09-3.88, P = 0.025; OR = 2.09, 95% CI = 1.23-3.60, P = 0.007; and OR = 1.95, 95% CI = 1.15-3.35, P = 0.014 for rs11506105, rs12979860 and rs11881222, respectively). In conclusion, EGFR and IL28B SNPs are strong independent predictive markers of spontaneous viral clearance. © 2015 Macmillan Publishers Limited All rights reserved.
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