Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation

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Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation Pubmed

Namdari H¹ ; Sadeghi A¹ ; Rouchi AH²

Show Affiliations

1. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Kidney Diseases Published:2021

Abstract

Solid organ transplant recipients are in high demand for developed immune-modulating agents to control allo-immune responses following transplantation. The immunosuppressive agents offer the recipients improved short-term graft survival; nonetheless, this benefit is tempered by unavoidable long-term adverse events of these medications. Active control of allo-response using therapeutic cell transfer has gained much attraction during the last few years. It is widely established that regulatory T cells (Tregs) control immune responsiveness to allo-antigens and contribute to the induction of tolerance. Here, it is aimed to review recent results regarding Tregs and chimeric antigen receptor (CAR) Tregs therapy in solid organ transplantation and discuss strategies to overcome technical challenges of developing successful Tregs/CAR Tregs therapy. © 2021, Iranian Society of Nephrology. All rights reserved.

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Style	Citing Format
MLA	Namdari H, Sadeghi A, Rouchi AH. "Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation." Iranian Journal of Kidney Diseases, vol. 15, no. 2, 2021, pp. 82-94.
APA	Namdari H, Sadeghi A, Rouchi AH (2021). Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation. Iranian Journal of Kidney Diseases, 15(2), 82-94.
Chicago	Namdari H, Sadeghi A, Rouchi AH. "Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation." Iranian Journal of Kidney Diseases 15, no. 2 (2021): 82-94.
Harvard	Namdari H, Sadeghi A, Rouchi AH (2021) 'Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation', Iranian Journal of Kidney Diseases, 15(2), pp. 82-94.
Vancouver	Namdari H, Sadeghi A, Rouchi AH. Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation. Iranian Journal of Kidney Diseases. 2021;15(2):82-94.
BibTex	@article{ author = {Namdari H and Sadeghi A and Rouchi AH}, title = {Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation}, journal = {Iranian Journal of Kidney Diseases}, volume = {15}, number = {2}, pages = {82-94}, year = {2021} }
RIS	TY - JOUR AU - Namdari H AU - Sadeghi A AU - Rouchi AH TI - Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation JO - Iranian Journal of Kidney Diseases VL - 15 IS - 2 SP - 82 EP - 94 PY - 2021 ER -

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