Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors

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Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors Publisher Pubmed

Saeedi M^{1, 2} ; Mohammadikhanaposhtani M³ ; Asgari MS⁴ ; Eghbalnejad N⁵ ; Imanparast S⁶ ; Faramarzi MA⁶ ; Larijani B⁷ ; Mahdavi M⁷ ; Akbarzadeh T^{2, 8}

Source: Bioorganic and Medicinal Chemistry Published:2019

Abstract

In this work, new derivatives of diarylimidazole-1,2,3-triazole 7a-p were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory activity. All compounds showed potent inhibitory activity in the range of IC50 = 90.4–246.7 µM comparing with acarbose as the standard drug (IC50 = 750.0 µM). Among the synthesized compounds, compounds 7b, 7c, and 7e were approximately 8 times more potent than acarbose. The kinetic study of those compounds indicated that they acted as the competitive inhibitors of α-glucosidase. Molecular docking studies were also carried out for compounds 7b, 7c, and 7e using modeled α-glucosidase to find the interaction modes responsible for the desired inhibitory activity. © 2019 Elsevier Ltd

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Style	Citing Format
MLA	Saeedi M, et al.. "Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors." Bioorganic and Medicinal Chemistry, vol. 27, no. 23, 2019, pp. -.
APA	Saeedi M, Mohammadikhanaposhtani M, Asgari MS, Eghbalnejad N, Imanparast S, Faramarzi MA, Larijani B, Mahdavi M, Akbarzadeh T (2019). Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors. Bioorganic and Medicinal Chemistry, 27(23), -.
Chicago	Saeedi M, Mohammadikhanaposhtani M, Asgari MS, Eghbalnejad N, Imanparast S, Faramarzi MA, Larijani B, Mahdavi M, Akbarzadeh T. "Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors." Bioorganic and Medicinal Chemistry 27, no. 23 (2019): -.
Harvard	Saeedi M et al. (2019) 'Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors', Bioorganic and Medicinal Chemistry, 27(23), pp. -.
Vancouver	Saeedi M, Mohammadikhanaposhtani M, Asgari MS, Eghbalnejad N, Imanparast S, Faramarzi MA, et al.. Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors. Bioorganic and Medicinal Chemistry. 2019;27(23):-.
BibTex	@article{ author = {Saeedi M and Mohammadikhanaposhtani M and Asgari MS and Eghbalnejad N and Imanparast S and Faramarzi MA and Larijani B and Mahdavi M and Akbarzadeh T}, title = {Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors}, journal = {Bioorganic and Medicinal Chemistry}, volume = {27}, number = {23}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Saeedi M AU - Mohammadikhanaposhtani M AU - Asgari MS AU - Eghbalnejad N AU - Imanparast S AU - Faramarzi MA AU - Larijani B AU - Mahdavi M AU - Akbarzadeh T TI - Design, Synthesis, in Vitro, and in Silico Studies of Novel Diarylimidazole-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors JO - Bioorganic and Medicinal Chemistry VL - 27 IS - 23 SP - EP - PY - 2019 ER -

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