The Comparison of the Efficacy of Intramuscular Tetracosactide and Subacromial Triamcinolone Injection in Rotator Cuff Tendinitis: A Randomized Trial Publisher



Orandi AH¹ ; Mansour A¹ ; Bagheri N² ; Majedi H^{3, 4} ; Emami Meibodi SA^{3, 4} ; Pestehei SK⁵ ; Saberian P⁵ Show Affiliations
Source: Rheumatology Advances in Practice Published:2025

Abstract

Objectives: Rotator cuff tendinitis (RCT) is a tendon inflammation often following subacromial impingement syndrome. One of the non-surgical management modalities for RCT is subacromial injection of corticosteroids. Some studies have claimed a correlation between ACTH (Adrenocorticotropic Hormone) deficiency and rotator cuff lesions; hence, intramuscular ACTH analogue injection has been recommended as an option. This research aimed to compare the effectiveness of these two treatment methods. Methods: We conducted a study with 86 patients suffering from RCT. The patients were randomly divided into two groups of 43; one group received a subacromial injection of 40 mg of triamcinolone acetonide, while the other group received 1 mg of intramuscular tetracosactide injection. We recorded the Constant-Murley (CM) and visual analogue scale (VAS) scores for each patient before and 4 weeks after injections to measure pain acuity and joint functionality. Later, we compared and analysed the two scores in each group. Results: Based on the statistical analysis, the mean ages of the participants in the triamcinolone and tetracosactide groups were 53.21 ± 11.37 and 54.56 ± 11.98, respectively. Both groups demonstrated an improvement in VAS for pain and CM scores (P < 0.05). However, the VAS for pain score decreased, and the CM score increased more significantly in the triamcinolone group than in the tetracosactide group (P < 0.05). Conclusion: Although both treatment methods exhibit promise for pain relief, subacromial injection of triamcinolone appears more efficacious than intramuscular injection of tetracosactide in patients with RCT, based on a 4-week follow-up. Trial registration: Iranian Registry of Clinical Trials, https://irct.behdasht.gov.ir, IRCT20240110060673N1. © 2024 The Author(s).