Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study

Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study Publisher

Mortezaee FT¹ ; Chaleshtori MH¹ ; Kheiri S² ; Farrokhi E¹ ; Shariati L³ ; Tabatabaiefar MA^{1, 4} ; Miraj S⁵

Show Affiliations

1. Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3. Department of Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. Deparmment of Obstetrics of Gynecology, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Biosciences Biotechnology Research Asia Published:2015

Abstract

Uterine leiomyoma (UL) or fibroid is the most common estrogen- dependent tumor of the reproductive system. Almost a quarter of women at reproductive age are affected with this benign tumor. The purpose of the present study was to investigate the possible association of IL-1β-511and IL-1β 3954 polymorphisms with UL in the women of Charmahal & Bakhtiari province of Iran. Totally, 276 patients with UL and 157 healthy control women were studied. The genetic polymorphisms for IL-1β-511and IL-1β 3954 were analyzed by PCR-RFLP method. The results were analyzed with SPSS software using χ2 test. The TC genotypes of the IL-1β -511C/T polymorphism showed a decreased risk of UL (OR = 0.232, P = 0.01, 95 % CI = 0.11 - 0.48). A significant difference was found for the C allele frequencies of the IL-1 β -511 C>T polymorphism between the two groups (OR = 0.232, P = 0.01, 95% CI = 0.11 - 0.48). However, no significant difference was found for the IL-1 a -3954 polymorphism between the two groups. Our findings indicated that IL-1 a -511C>T promoter polymorphism affects the risk of UL in the women of our study and this polymorphism might be involved in the pathogens of this disease.

Style	Citing Format
MLA	Mortezaee FT, et al.. "Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study." Biosciences Biotechnology Research Asia, vol. 12, no. 1, 2015, pp. 341-345.
APA	Mortezaee FT, Chaleshtori MH, Kheiri S, Farrokhi E, Shariati L, Tabatabaiefar MA, Miraj S (2015). Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study. Biosciences Biotechnology Research Asia, 12(1), 341-345.
Chicago	Mortezaee FT, Chaleshtori MH, Kheiri S, Farrokhi E, Shariati L, Tabatabaiefar MA, Miraj S. "Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study." Biosciences Biotechnology Research Asia 12, no. 1 (2015): 341-345.
Harvard	Mortezaee FT et al. (2015) 'Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study', Biosciences Biotechnology Research Asia, 12(1), pp. 341-345.
Vancouver	Mortezaee FT, Chaleshtori MH, Kheiri S, Farrokhi E, Shariati L, Tabatabaiefar MA, et al.. Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study. Biosciences Biotechnology Research Asia. 2015;12(1):341-345.
BibTex	@article{ author = {Mortezaee FT and Chaleshtori MH and Kheiri S and Farrokhi E and Shariati L and Tabatabaiefar MA and Miraj S}, title = {Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study}, journal = {Biosciences Biotechnology Research Asia}, volume = {12}, number = {1}, pages = {341-345}, year = {2015} }
RIS	TY - JOUR AU - Mortezaee FT AU - Chaleshtori MH AU - Kheiri S AU - Farrokhi E AU - Shariati L AU - Tabatabaiefar MA AU - Miraj S TI - Interleukin-1 Β Gene Polymorphisms in Iranian Patients With Uterine Fibroid, a Case-Control Study JO - Biosciences Biotechnology Research Asia VL - 12 IS - 1 SP - 341 EP - 345 PY - 2015 ER -

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