Risk Factors for the Mortality in Hospitalized Patients With Covid-19: A Brief Report Publisher Pubmed

Summary: Iranian study of 408 COVID patients flags high blood cell ratios, kidney markers, lung issues as death risks. Early lab scans could spot severe cases sooner—vital for outcomes. #COVID19 #PandemicRisks

Sami R¹ ; Hajian MR¹ ; Amra B² ; Soltaninejad F¹ ; Mansourian M³ ; Mirfendereski S⁴ ; Sadegh R⁵ ; Khademi N¹ ; Jalali S⁶ ; Shokrimashhadi N⁷
Source: Iranian Journal of Medical Sciences Published:2021

Abstract

The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission’s medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24th to April 12th, 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (P<0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients. © 2021, Shriaz University of Medical Sciences. All rights reserved.