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Cycloartanes From Euphorbia Aellenii Rech. F. and Their Antiproliferative Activity



Ayatollahi AM1 ; Ghanadian M2 ; Afsharypuor S3 ; Mesaik MA4 ; Abdalla OM4 ; Shahlaei M5 ; Farzandi G6 ; Mostafavi H6
Authors

Source: Iranian Journal of Pharmaceutical Research Published:2011

Abstract

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity. © 2011 by School of Pharmacy.
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