Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia

Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia

Nadali F¹ ; Ferdowsi S³ ; Karimzadeh P³ ; Chahardouli B² ; Einollahi N³ ; Mousavi SA² ; Bahar B² ; Dargahi H³ ; Alimoghaddam K² ; Ghavamzadeh A² ; Ghaffari SH²

Show Affiliations

1. Pathology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Hematology-Oncology and BMT Research Center, Shariati Hospital, Tehran University of Medical Sciences, Iran
3. School of Allied Health Sciences, Tehran University of Medical Sciences, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2009

Abstract

JAK2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. A single acquired point mutation - V617F - in JAK2 occurs in the great majority of patients with polycythemia vera (PV) and approximately half of the patients with idiopathic myelofibrosis (IMF) or essential thrombocythemia (ET). In contrast, the JAK2-V617F mutation is only rarely found in chronic myeloid leukemia (CML) but, recently, some authors have reported the coexistence of JAK2V617F and BCR/ABL+ in CML patients expressing the p210 BCR-ABL oncoprotein. Here, we report a CML patient with the expression of p210/b2a2 type BCR-ABL transcript and JAK2V617F mutation.

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Style	Citing Format
MLA	Nadali F, et al.. "Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia." International Journal of Hematology-Oncology and Stem Cell Research, vol. 3, no. 4, 2009, pp. 43-45.
APA	Nadali F, Ferdowsi S, Karimzadeh P, Chahardouli B, Einollahi N, Mousavi SA, Bahar B, Dargahi H, Alimoghaddam K, Ghavamzadeh A, Ghaffari SH (2009). Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia. International Journal of Hematology-Oncology and Stem Cell Research, 3(4), 43-45.
Chicago	Nadali F, Ferdowsi S, Karimzadeh P, Chahardouli B, Einollahi N, Mousavi SA, Bahar B, et al.. "Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia." International Journal of Hematology-Oncology and Stem Cell Research 3, no. 4 (2009): 43-45.
Harvard	Nadali F et al. (2009) 'Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia', International Journal of Hematology-Oncology and Stem Cell Research, 3(4), pp. 43-45.
Vancouver	Nadali F, Ferdowsi S, Karimzadeh P, Chahardouli B, Einollahi N, Mousavi SA, et al.. Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia. International Journal of Hematology-Oncology and Stem Cell Research. 2009;3(4):43-45.
BibTex	@article{ author = {Nadali F and Ferdowsi S and Karimzadeh P and Chahardouli B and Einollahi N and Mousavi SA and Bahar B and Dargahi H and Alimoghaddam K and Ghavamzadeh A and Ghaffari SH}, title = {Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia}, journal = {International Journal of Hematology-Oncology and Stem Cell Research}, volume = {3}, number = {4}, pages = {43-45}, year = {2009} }
RIS	TY - JOUR AU - Nadali F AU - Ferdowsi S AU - Karimzadeh P AU - Chahardouli B AU - Einollahi N AU - Mousavi SA AU - Bahar B AU - Dargahi H AU - Alimoghaddam K AU - Ghavamzadeh A AU - Ghaffari SH TI - Jak2-V617f Mutation and Philadelphia Positive Chronic Myeloid Leukemia JO - International Journal of Hematology-Oncology and Stem Cell Research VL - 3 IS - 4 SP - 43 EP - 45 PY - 2009 ER -

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