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Characterization of Drug Release and Diffusion Mechanism Through Hydroxyethylmethacrylate/Methacrylic Acid Ph-Sensitive Hydrogel Publisher Pubmed



Varshosaz J1 ; Hajian M2
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, P.O. Box 81745-359, Iran
  2. 2. Department of Chemistry, School of Sciences, Isfahan University, Isfahan, Iran

Source: Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents Published:2004


Abstract

Hydroxyethylmethacrylate/methacrylic acid copolymer cross-linked with ethylenglycol dimethacrylate was prepared by a bulk free radical polymerization method. The permeability studies of this pH-sensitive hydrogel to drugs with different water solubilities showed a water-content dependent diffusion or pore mechanism for ephedrine HCl (water-soluble model drug), whereas, a partition or solute-diffusion mechanism for indomethacin (a water-insoluble drug) was seen. Data analysis of release tests, according to the swelling interface number and Peppas equation for ephedrine HCl in pH 7.4, showed a biexponential model kinetic, whereas in pH 1.2 a swelling-controlled mechanism was seen. Indomethacin was released by an anomalous or non-Fickian release kinetics.
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