Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Fatal Case of Bloodstream Infection by Fusarium Solani in a Patient With Adrenocortical Carcinoma From Isfahan, Iran Publisher



Rajabzadeh A1 ; Shokri D2 ; Aboutalebian S3 ; Morovati H4 ; Mohammadi A3 ; Samani RE5 ; Mohammadi R6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Infectious Diseases Specialist, Isfahan Milad Hospital, Isfahan, Iran
  2. 2. Department of Microbiology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran
  3. 3. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Medical Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Cancer Management Published:2020


Abstract

Introduction: Fusarium species are hyaline saprophytic fungi that are frequently found in the soil, air, and water. They can cause severe systemic infections in immunocompromised patients. Clinical manifestations depend on the way of entry of the mold and host immune system status. The main ways of entrance are the airways, skin, and mucosal membranes. Disseminated fusariosis often occurs in patients with hematological disorders, patients with cancer, and solid organ transplant recipients. Case Presentation: Herein we report a case of Fusarium fungemia in a patient with adrenocortical carcinoma from Isfahan, Iran. The patient was a 41-year-old female with stage III adrenal cortical carcinoma. Despite antifungal therapy with liposomal amphotericin B, the patient passed away 6 days after admission. Internal transcribed spacer region sequencing applied for species identification and its sequence deposited in the GenBank (accession number: MK880379). Conclusions: Since the ideal strategies against invasive fungal infections remain uncertain and the mortality rate is high, we recommend primary prophylaxis with a broad-spectrum antifungal agent for vulnerable patients particularly those admitted to high-risk units such as oncology, hematology, and transplant units. © 2020, Author(s).
Related Docs
View other Related Docs
1. Invasive Fusarium Rhinosinusitis in Covid-19 Patients: Report of Three Cases With Successful Management, Frontiers in Cellular and Infection Microbiology (2023)
2. In Vitro Antifungal Susceptibility Profile of Miltefosine Against a Collection of Azole and Echinocandins Resistant Fusarium Strains, Journal of Fungi (2022)
3. Fusarium Proliferatum-Induced Chronic Lip Ulcer: Successful Treatment With Itraconazole: A Case Report, Journal of Medical Case Reports (2022)
4. Phaeohyphomycosis Caused by Neoscytalidium Dimidiatum in a Covid-19 Patient; [Feohifomicosis Producida Por Neoscytalidium Dimidiatum En Un Paciente Con Covid-19], Revista Iberoamericana de Micologia (2022)
5. Invasive Fungal Infection in Febrile Patients With Hematologic Malignancies Undergoing Chemotherapy in Iran, Endocrine, Metabolic and Immune Disorders - Drug Targets (2019)
6. In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs, Mycoses (2015)
7. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
8. Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of Tr34/L98h- and Tr46/Y121f/T289a-Positive Aspergillus Fumigatus Isolates Obtained From Patients in Iran From 2010 to 2014, Antimicrobial Agents and Chemotherapy (2016)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (15)
Seyed Hossein Mirhendi Esfahani (5)
Other Related Docs
9. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
10. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
11. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)
12. Molecular Detection of Candida Spp. and Aspergillus Fumigatus in Bronchoalveolar Lavage Fluid of Patients With Ventilator-Associated Pneumonia, Journal of Research in Medical Sciences (2014)
13. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
14. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
15. Otomycosis in Central Iran: A Clinical and Mycological Study, Iranian Red Crescent Medical Journal (2011)
16. Non-Invasive Methods to Diagnose Fungal Infections in Pediatric Patients With Hematologic Disorders, Jundishapur Journal of Microbiology (2016)
17. First Fatal Cerebral Phaeohyphomycosis Due to Rhinocladiella Mackenziei in Iran, Based on Its Rdna, Journal de Mycologie Medicale (2015)
18. Otomycosis Due to the Rare Fungi Talaromyces Purpurogenus, Naganishia Albida and Filobasidium Magnum, Mycopathologia (2020)
19. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)
20. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
21. Invasive Fungal Infections in Hematologic Malignancies: Incidence, Management, and Antifungal Therapy, Journal of Research in Medical Sciences (2023)
22. Candida Infections Among Neutropenic Patients, Caspian Journal of Internal Medicine (2016)
23. A 9-Year Experience of Aspergillus Infections From Isfahan, Iran, Infection and Drug Resistance (2020)
24. Isolation of Opportunistic Fungi From Bronchoalveolar Lavage of Compromised Hosts in Isfahan, Iran, Mycopathologia (1996)
25. Comparison of in Vitro Activities of Newer Triazoles and Classic Antifungal Agents Against Dermatophyte Species Isolated From Iranian University Hospitals: A Multi-Central Study, Annals of Clinical Microbiology and Antimicrobials (2023)
26. Multicenter Study of Susceptibility of Aspergillus Species Isolated From Iranian University Hospitals to Seven Antifungal Agents, Microbiology Spectrum (2022)
27. In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex, Mycopathologia (2016)