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Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus Publisher



Khashayar A1 ; Bahari Z2, 3 ; Elliyeh M1 ; Ghasemi M4
Authors
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Authors Affiliations
  1. 1. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Revista Brasileira de Farmacognosia Published:2021


Abstract

The incidences of diabetes mellitus and other metabolic diseases are increasing worldwide. However, the current treatments for diabetes mellitus and other metabolic diseases are far from being clearly understood. Berberis species from the Barberry family, Berberidaceae, better known as Barberries are widely distributed worldwide. Several extracts and compounds obtained from Berberis species, particularly berberine, revealed effectiveness in the treatment of diabetes mellitus and other metabolic diseases. In the present study, a systematic search in the literature was performed to provide animal and clinical evidences regarding the therapeutic effects of berberine in metabolic diseases and diabetes mellitus. Also, its possible mechanism of action is described, in addition to the reported complication for berberine use and its drug interactions. Graphical abstract: [Figure not available: see fulltext.]. © 2021, Sociedade Brasileira de Farmacognosia.
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