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Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells Publisher Pubmed



Azari Matin A1 ; Fattah K2 ; Saeidpour Masouleh S3 ; Tavakoli R4 ; Houshmandkia SA5 ; Moliani A6 ; Moghimimonfared R7 ; Pakzad S8 ; Dalir Abdolahinia E9
Authors
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Authors Affiliations
  1. 1. Department of Biology, California State University, Northridge, CA, United States
  2. 2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnologies, University of Siena, Siena, Italy
  4. 4. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Turkey
  6. 6. Isfahan Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran
  8. 8. Department of Oral and Maxillofacial Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Biomaterials Science, Polymer Edition Published:2022


Abstract

Continuous remodeling is not able to repair large bone defects. Bone tissue engineering is aimed to repair these defects by creating bone grafts. To do this, several technologies and biomaterials have been employed to fabricate an in vivo-like supportive matrix. Electrospinning is a versatile technique to fabricate porous matrices with interconnected pores and high surface area, replicating in vivo microenvironment. Electrospun scaffolds have been used in a large number of studies to provide a matrix for bone regeneration and osteogenic differentiation of stem cells such as induced pluripotent stem cells (iPSCs). Electrospinning uses both natural and synthetic polymers, either alone or in combination, to fabricate scaffolds. Among them, synthetic polymers have had a great promise in bone regeneration and repair. They allow the fabrication of biocompatible and biodegradable scaffolds with high mechanical properties, suitable for bone engineering. Furthermore, several attempts have done to increase the osteogenic properties of these scaffolds. This paper reviewed the potential of synthetic electrospun scaffolds in osteogenic differentiation of iPSCs. In addition, the approaches to improve the osteogenic differentiation of these scaffolds are addressed. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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