Determinants of Quality of Life in Breast Cancer: Meta-Analytic Structural Equation Modeling of Studies Publisher

Summary: Meta-analysis shows physical activity, fatigue, & stress as key factors affecting quality of life in breast cancer patients. #BreastCancer #QualityOfLife

Mansourian M¹ ; Bazrafshan R^{2, 3} ; Malakoutikhah Z⁴ ; Jafarikoshki T⁵ ; Vaseghi G⁴
Source: European Journal of Cancer Care Published:2023

Abstract

Objective. Quality of life (QoL) is a major concern in breast cancer (BC) patients. Despite efforts, no study has comprehensively addressed determinants of QoL in patients with BC. This study aimed to synthesize evidence on QoL correlations using the meta-analytic structural equation modeling (MASEM) approach. Methods. Our search in PubMed, Web of Science, Scopus, and Cochrane databases resulted in 5, 238 initial relevant papers, 73 of which were eligible for final analysis with a total of 44, 121 patients. We used a two-stage procedure of correlation-based MASEM to examine the relationship between QoL and body mass index (BMI), physical activity (PA), sleep, depression, fatigue, and stress. Results. Final MASEM model suggested that PA (path coefficient = 0.33, 95% CI = −0.0444; 0.6334), fatigue (path coefficient = −0.23, 95% CI = −0.6825; 0.0361), and stress (path coefficient = −0.22, 95% CI = −0.5143; 0.6875) were the most important factors related to QoL in patients with breast cancer. Final model identified variables responsible for 68% of the variation in QoL in BC. Conclusion. QoL is an important outcome in the treatment course of BC. Large-scale and meta-analysis studies could help patients to have a life with improved quality. Copyright © 2023 Marjan Mansourian et al.