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Mir-196: Emerging of a New Potential Therapeutic Target and Biomarker in Colorectal Cancer Publisher Pubmed



Pourdavoud P1 ; Pakzad B2 ; Mosallaei M3 ; Saadatian Z4 ; Esmaeilzadeh E5 ; Alimolaie A6 ; Shaygannejad A7
Authors
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Authors Affiliations
  1. 1. Iranian Red Crescent Society, Tehran, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. Faculty of Medicine, AJA University of Medical Science, Tehran, Iran
  6. 6. Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
  7. 7. Department of Internal Medicine (Gastrointestinal Division), Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Source: Molecular Biology Reports Published:2020


Abstract

Deregulation of microRNAs, as key elements in colorectal cancer (CRC) pathogenesis, is correlated with various stages of this cancer. miR-196 is involved in the initiation and progression of a verity of malignances, especially CRC. miR-196 in CRC cells could target different types of genes with oncogenic and/or tumor suppressor function such as HOX genes, GATA6, SOCS1, SOCS3, ANXA1, DFFA, PDCD4, ZG16 and ING5. Therefore, these genes could be up or down-regulated in cells and subsequently change the capacity of CRC cells in terms of tumor development, progression and, response to therapy. Comprehension of miR-196-associated aberrations underlying the CRC pathogenesis might introduce promising targets for therapy. Additionally, it seems that miR-196 expression profiling, especially circulatory exosomal miR-196, might be useful for diagnosis and prognosis determination of the CRC patients. In this review, at first, we summarize the roles of miR-196 in different types of cancers. After that, a detailed discussion about this miRNA and also their targets in CRC pathogenesis, progression, and response to treatment are represented. Moreover, we highlight the potential utilization of miR-196 and its targets as therapeutic targets and novel biomarkers in early detection and prediction of prognosis in CRC patients. © 2020, Springer Nature B.V.
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