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Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance Publisher



Fattahi M1, 2 ; Rezaee D3 ; Fakhari F4 ; Najafi S5, 6 ; Aghaeizarch SM7 ; Beyranvand P8 ; Rashidi MA9 ; Bagherimohammadi S10 ; Zamanirarani F11 ; Bakhtiari M12 ; Bakhtiari A13 ; Falahi S14 ; Kenarkoohi A14, 15 ; Majidpoor J16 Show All Authors
Authors
  1. Fattahi M1, 2
  2. Rezaee D3
  3. Fakhari F4
  4. Najafi S5, 6
  5. Aghaeizarch SM7
  6. Beyranvand P8
  7. Rashidi MA9
  8. Bagherimohammadi S10
  9. Zamanirarani F11
  10. Bakhtiari M12
  11. Bakhtiari A13
  12. Falahi S14
  13. Kenarkoohi A14, 15
  14. Majidpoor J16
  15. Nguyen PU1, 2
Show Affiliations
Authors Affiliations
  1. 1. Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam
  2. 2. School of Engineering & Technology, Duy Tan University, Da Nang, Viet Nam
  3. 3. School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran
  4. 4. Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Molecular Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
  9. 9. Student Research Committee, Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  13. 13. Anatomical Sciences Department, Medical Faculty, Hamadan University of Medical Sciences, Hamadan, Iran
  14. 14. Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran
  15. 15. Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  16. 16. Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran

Source: Cell Death Discovery Published:2023


Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance. © 2023, The Author(s).
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