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Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance Publisher



Fattahi M1, 2 ; Rezaee D3 ; Fakhari F4 ; Najafi S5, 6 ; Aghaeizarch SM7 ; Beyranvand P8 ; Rashidi MA9 ; Bagherimohammadi S10 ; Zamanirarani F11 ; Bakhtiari M12 ; Bakhtiari A13 ; Falahi S14 ; Kenarkoohi A14, 15 ; Majidpoor J16 Show All Authors
Authors
  1. Fattahi M1, 2
  2. Rezaee D3
  3. Fakhari F4
  4. Najafi S5, 6
  5. Aghaeizarch SM7
  6. Beyranvand P8
  7. Rashidi MA9
  8. Bagherimohammadi S10
  9. Zamanirarani F11
  10. Bakhtiari M12
  11. Bakhtiari A13
  12. Falahi S14
  13. Kenarkoohi A14, 15
  14. Majidpoor J16
  15. Nguyen PU1, 2

Source: Cell Death Discovery Published:2023


Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance. © 2023, The Author(s).
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