Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance Publisher



Fattahi M^{1, 2} ; Rezaee D³ ; Fakhari F⁴ ; Najafi S^{5, 6} ; Aghaeizarch SM⁷ ; Beyranvand P⁸ ; Rashidi MA⁹ ; Bagherimohammadi S¹⁰ ; Zamanirarani F¹¹ ; Bakhtiari M¹² ; Bakhtiari A¹³ ; Falahi S¹⁴ ; Kenarkoohi A^{14, 15} ; Majidpoor J¹⁶ Show All Authors
Source: Cell Death Discovery Published:2023

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with a short length of 19–22 nucleotides. miRNAs are posttranscriptional regulators of gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is a well-studied miRNA, for which most studies report its downregulation in cancer cells and tissues and experiments support its role as a tumor suppressor inhibiting malignant biological behaviors of cancer cells in vitro and in vivo. To exert its functions, miR-184 affects some signaling pathways involved in tumorigenesis like Wnt and β-catenin, and AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such as Bcl-2. Interestingly, clinical investigations have shown miR-184 with good performance as a prognostic/diagnostic biomarker for various cancers. Additionally, exogenous miR-184 in cell and xenograft animal studies suggest it as a therapeutic anticancer target. In this review, we outline the studies that evaluated the roles of miR-184 in tumorigenesis as well as its clinical significance. © 2023, The Author(s).