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Green Sonochemical Synthesis Platinum Nanoparticles As a Novel Contrast Agent for Computed Tomography Publisher



Jameel MS1, 2 ; Aziz AA1, 2 ; Dheyab MA1, 2 ; Mehrdel B3 ; Khaniabadi PM4 ; Khaniabadi BM5
Authors
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Authors Affiliations
  1. 1. Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
  2. 2. Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
  3. 3. New Technologies Research Center, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  4. 4. Department of Radiology and Molecular Imaging, College of Medicine and Health Science, Sultan Qaboos University, PO. Box: 35, 123, Al Khod, Muscat, Oman
  5. 5. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Materials Today Communications Published:2021


Abstract

Computed tomography (CT) imaging can be enhanced with the use of contrast agents. However, the conventionally used clinical small-molecule agents (Omnipaque) are encumbered by an array of constraints that include potentially toxic and unwanted side effects. Therefore, this study presents a facile plant-assisted synthesis of platinum nanoparticles (Pt NPs) that employs ultrasonic irradiation to improve the Hounsfield (HU) values for CT imaging. This “one-step one-pot”, eco-friendly and simple approach produced highly stable, biocompatible and ultrasmall Pt NPs colloidal with a mean diameter of 3.8 nm. The extract from Prosopis farcta (P. farcta) fruits served as both a reducing agent and stabilizer. The cell viability test demonstrated that HEK-293 cells remained viable after being subjected to high concentrations of Pt NPs. The X-ray attenuation of the as-synthesized Pt NPs (HU = 355) exceeds those of commercial NPs and conventionally prepared NPs. Thus, this research gives new insights into the use of plants to prepare novel contrast agents for molecular imaging. © 2021 Elsevier Ltd
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