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Male Sex Is Independently Associated With Faster Disability Accumulation in Relapse-Onset Ms But Not in Primary Progressive Ms Publisher Pubmed



Ribbons KA1 ; Mcelduff P2 ; Boz C3 ; Trojano M4 ; Izquierdo G5 ; Duquette P6 ; Girard M6 ; Grandmaison F7 ; Hupperts R8 ; Grammond P9 ; Orejaguevara C10 ; Petersen T11 ; Bergamaschi R12 ; Giuliani G13 Show All Authors
Authors
  1. Ribbons KA1
  2. Mcelduff P2
  3. Boz C3
  4. Trojano M4
  5. Izquierdo G5
  6. Duquette P6
  7. Girard M6
  8. Grandmaison F7
  9. Hupperts R8
  10. Grammond P9
  11. Orejaguevara C10
  12. Petersen T11
  13. Bergamaschi R12
  14. Giuliani G13
  15. Barnett M14
  16. Van Pesch V15
  17. Amato MP16
  18. Iuliano G17
  19. Fiol M18
  20. Slee M19
  21. Verheul F20
  22. Cristiano E21
  23. Fernandezbolanos R22
  24. Saladino ML23
  25. Rio ME24
  26. Cabreragomez J25
  27. Butzkueven H26
  28. Van Munster E27
  29. Brabermoerland LD28
  30. Spitaleri DL29
  31. Lugaresi A30
  32. Shaygannejad V31
  33. Gray O32
  34. Deri N33
  35. Alroughani R34
  36. Lechnerscott J1

Source: PLoS ONE Published:2015


Abstract

Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change. Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar. © 2015 Ribbons et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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