Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Effects of Garcinia Cambogia (Hydroxycitric Acid) on Serum Leptin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed

Summary: Garcinia cambogia may lower leptin levels, aiding weight control, study suggests. Findings vary, urging further research. #WeightLoss #Nutrition

Amini MR1, 2 ; Salavatizadeh M3 ; Kazeminejad S4 ; Javadi F4 ; Hajiaqaei M5 ; Askari G2 ; Hekmatdoost A3
Authors

Source: Complementary Therapies in Medicine Published:2024


Abstract

Objective: The observed impacts of Garcinia cambogia (GC) on serum leptin indicate inconsistency. We performed a systematic review and meta-analysis on randomized controlled trials (RCTs) to evaluate the effectiveness of GC on leptin levels. Methods: A thorough literature search was carried out using different online databases, including Scopus, Web of Science, PubMed, and Google Scholar, until May 25, 2024. Using random effects, weighted mean differences (WMDs) and corresponding 95 % confidence intervals (CIs) were computed. Standard procedures were followed to account for publication bias, study quality, and statistical heterogeneity. Results: In this meta-analysis, a total of eight eligible trials with 330 participants were ultimately included. Quality assessment showed that half of the included trials were considered to have fair quality, while the other half were deemed to have poor quality. Our analysis, with no indication of publication bias, showed a significantly decreased effect of GC on leptin compared with the placebo (WMD: −5.01 ng/ml; 95 % CI: −9.22 to −0.80, p = 0.02). However, significant heterogeneity was detected between studies (I2 =93.5 %, p < 0.001). The Hartung-Knapp adjustment did not affect our results. Subgroup analysis revealed that GC consumption represents the most effects in trials with sample size ≥ 50 (WMD: −3.63 ng/ml; 95 % CI [−5.51, −1.76], p < 0.001), and mean age of participants ≥ 30 years (WMD: −7.43 ng/ml; 95 % CI [−9.31, −5.56], p < 0.001). Conclusions: The findings of the present study showed that leptin levels might decline following GC administration. Registration number: CRD42023486370 © 2024
Other Related Docs
5. A Systematic Review on the Clinical Significance of Nutraceuticals for Weight Loss, Australian Journal of Herbal and Naturopathic Medicine (2023)