Tooth Graft and Platelet-Rich Fibrin Mixture for Oral Bone Reconstruction and Preservation: A Scoping Review Publisher Pubmed



M Shekarian MINA ; F Aghajani FATEMEH ; Zsm Hejazi Zahra Sadat MOHAJER ; P Iranmanesh PEDRAM ; Bm Akbaribezenjani Bahamin MOUSA ; Aa Khademi Abbasali ALI
Source: Clinical and Experimental Dental Research Published:2025

Abstract

Aim: This scoping review aimed to evaluate effectiveness of using tooth graft (TG) mixture with platelet-rich fibrin (PRF), examining their roles in oral bone reconstruction and preservation, and evaluating the clinical and histopathological outcomes associated with this approach. Material and Methods: Articles were searched in Scopus, Medline, Web of Science, ProQuest, and Google Scholar up to November 2024. The search was guided by the PCC framework: Population: alveolar bone and calvaria bone defects; Concept: the use of a TG mixture with PRF as a bone graft material; Context: clinical and histopathological outcomes of oral bone reconstruction and preservation. Two independent researchers carried out the screening, study selection, and data extraction processes. Results: Use of the PRF and TG mixture for socket preservation is superior to using each of these biomaterials individually. However, in the context of bone reconstruction, although all studies confirm new bone formation, the superiority of this mixture over the separate use of each biomaterial remains uncertain. Additionally, all studies confirm the increase in bone density and new bone formation aimed at implant placement. Conclusion: The majority of studies have reported that the PRF and TG mixture enhances both the quality and quantity of bone. © 2025 Elsevier B.V., All rights reserved.