Association of Beverage Consumption With Cardio‑Metabolic Risk Factors and Alanine Transaminase Levels in Children and Adolescents: The Caspian‑V Study Publisher

Summary: Study links sugary drinks like soda to higher liver enzyme levels in kids, while milk and juice lower heart disease risk factors. #ChildHealth #HealthyDrinks

M Khademian MAJID ; A Shahsavari ALI ; M Qorbani MOSTFA ; Me Motlagh Mohammad ESMAEL ; R Heshmat RAMIN ; Es Khozani Elaheh SHAMS ; Ma Najafi Mohammad AMIN ; M Mansourian MARJAN ; R Kelishadi ROYA
Source: Advanced Biomedical Research Published:2024

Abstract

Background: This study aims to evaluate the association of beverage consumption with cardiometabolic risk factors and alanine transaminase (ALT) levels in children and adolescents. Materials and Methods: This nationwide study is a part of the fifth survey of a national surveillance program in Iran. Overall, 4200 students, aged 7–18 years, were selected from 30 provinces by multi‑stage cluster sampling. In addition to filling in questionnaires, blood sampling and biochemical tests were done. The weekly use of six different beverage types including milk, juice, tea, coffee, soda, and non‑alcoholic beer, was documented by interview. Results: The participation rate was 91.5% (n = 3843), and data of 3733 students were complete for the current study. Beverages containing high levels of sugar such as soda and non‑alcoholic beer were significantly associated with higher levels of ALT. Model coefficient of regression (SD) was 0.66 (0.31) (P value: 0.034). Healthy beverages such as milk and fresh juice and also beverages containing high levels of caffeine did not have significant association with ALT levels (P value = 0.32, P value = 0.60). Healthy beverages had a significant and inverse relationship with triglycerides (TG) (P value = 0.029), total cholesterol (TC) (P value = 0.008) and low‑density lipoprotein (LDL) (P value = 0.008) levels. Conclusion: This study showed that consuming sugar‑sweetened beverages is significantly associated with higher levels of ALT, whereas healthy beverages are associated with a better cardiometabolic profile meaning that consuming healthy beverages leads to lower TG, TC, and LDL levels. The effects of beverages on children’s health should be emphasized in health recommendations. © 2025 Elsevier B.V., All rights reserved.