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Surface Modification of Additive Manufactured Ti6al4v Scaffolds With Gelatin/Alginate- Igf-1 Carrier: An Effective Approach for Healing Bone Defects Publisher Pubmed



Mofazali P1 ; Atapour M1 ; Nakamura M2 ; Sheikholeslam M3 ; Galati M4 ; Saboori A4
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Medicity Research Laboratory, Faculty of Medicine, University of Turku Tykistokatu 6, Turku, 20520, Finland
  3. 3. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Integrated Additive Manufacturing Center (IAM), Department of Management and Production Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, Turino, 10129, Italy

Source: International Journal of Biological Macromolecules Published:2024


Abstract

The study investigates the potential of porous scaffolds with Gel/Alg-IGF-1 coatings as a viable candidate for orthopaedic implants. The scaffolds are composed of additively manufactured Ti6Al4V lattices, which were treated in an alkali solution to obtain the anatase and rutile phases. The treated surface exhibited hydrophilicity of <11.5°. A biopolymer carrier containing Insulin-like growth factor 1 was coated on the samples using immersion treatment. This study showed that the surface-modified porous Ti6Al4V scaffolds increased cell viability and proliferation, indicating potential for bone regeneration. The results demonstrate that surface modifications can enhance the osteoconduction and osteoinduction of Ti6Al4V implants, leading to improved bone regeneration and faster recovery. The porous Ti6Al4V scaffolds modified with surface coating of Gel/Alg-IGF-1 exhibited a noteworthy increase in cell viability (from 80.7 to 104.1%viability) and proliferation. These results suggest that the surface modified scaffolds have potential for use in treating bone defects. © 2024 Elsevier B.V.
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