Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments Publisher Pubmed



Sobhani T1 ; Shahbazigahrouei D1 ; Zahraei M2 ; Hejazi SH3 ; Dousti F4 ; Rostami M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  3. 3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Novel Drug Delivery Systems Research Centre and Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Cancer Research and Clinical Oncology Published:2023


Abstract

Purpose: Achieving new contrast enhancer agents that can produce high-resolution images in magnetic resonance imaging (MRI) with a minimum dose and side effects has always been important. Methods: Herein, the pegylated curcumin-coated manganese–zinc ferrite nanoparticles (MZF@CA-PEG-CUR NPs) have been reported as an MR imaging nanoprobe in hepatocellular carcinoma detection in the murine model for the first time. In vitro studies were done on HEPA 1–6 cancer cells and L929 as normal cells, and in vivo studies were done on hepatocellular carcinoma (HCC) using xenograft models of HCC. Results: The prepared NP had a diameter of 105 nm with narrow size distribution and was superparamagnetic with a saturated magnetization (Ms) of 39 emu/g. The NP was biocompatible without any significant hemolysis and cytotoxicity. Prussian blue staining showed more cellular uptake of HEPA 1–6 compared to L929 control cells after incubation (P < 0.05). The concentration of Fe in mice blood confirmed the plasma half-life of about 3 h; it seems the PEGylation increased the circulation time. ICP-OES of Fe showed the highest tumor localization for MZF@CA-CUR-PEG NPs, due to passive accumulation, compared to the other mice studied organs. The r2 relaxivity of NPs was 134.89 mM− 1 s− 1, and in vitro MRI demonstrated better effects in HEPA 1–6 cells than in L929 (P < 0.05). Also, in vivo MR images showed signal enhancement efficacy in tumor-bearing mice. Conclusion: This study demonstrated that the MZF@CA-CUR-PEG nanoprobe could be a promising candidate as an MR imaging agent in hepatocellular carcinoma early detection. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Related Docs
View other Related Docs
1. Assessment of Manganese-Zinc Ferrite Nanoparticles As a Novel Magnetic Resonance Imaging Contrast Agent for the Detection of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)
2. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
3. Synthesis and Application of Fe3o4@Au Composite Nanoparticles As Magnetic Resonance/Computed Tomography Dual-Modality Contrast Agent, Journal of Medical Signals and Sensors (2020)
4. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
5. Recent Nanotheranostics Applications for Cancer Therapy and Diagnosis: A Review, IET Nanobiotechnology (2021)
6. Study the Anti-Muc1 Antibody-Based Iron Oxide Nanoparticles on Three-Dimension Spheroid and Breast Cancer (Mcf-7) Cell Imaging, Polish Journal of Medical Physics and Engineering (2019)
7. Medical Imaging Modalities Using Nanoprobes for Cancer Diagnosis: A Literature Review on Recent Findings, Journal of Research in Medical Sciences (2019)
8. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (27)
Seyed Hossein Hejazi (5)
Other Related Docs
9. Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6, Journal of Isfahan Medical School (2021)
10. Detection of Muc1-Expressing Ovarian Cancer by C595 Monoclonal Antibody-Conjugated Spions Using Mr Imaging, The Scientific World Journal (2013)
11. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
12. Magnetic Iron Oxide Nanoparticles As T2 Mr Imaging Contrast Agent for Detection of Breast Cancer (Mcf-7) Cell, Avicenna Journal of Medical Biotechnology (2017)
13. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
14. Synthesis, Characterization and Mri Application of Cobalt-Zinc Ferrite Nanoparticles Coated With Dmsa: An In-Vivo Study, Applied Magnetic Resonance (2021)
15. Synthesis and in Vitro Evaluation of Mr Molecular Imaging Probes Using J591 Mab-Conjugated Spions for Specific Detection of Prostate Cancer, Contrast Media and Molecular Imaging (2013)
16. Therapeutic Effect of Deferrioxamine Conjugated to Pegylated Gold Nanoparticles and Complexed With Mn(Ii) Beside the Ct Scan and Mri Diagnostic Studies, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2019)
17. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
18. Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review, ACS Applied Nano Materials (2022)
19. Investigating the Sonodynamic-Radiosensitivity Effect of Gold Nanoparticles on Hela Cervical Cancer Cells, Journal of Korean Medical Science (2019)
20. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
21. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
22. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
23. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
24. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
25. Trastuzumab Conjugated Porphyrin-Superparamagnetic Iron Oxide Nanoparticle: A Potential Ptt-Mri Bimodal Agent for Herceptin Positive Breast Cancer, Photodiagnosis and Photodynamic Therapy (2020)
26. Functionalized Magnetic Nanoparticles for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices (2024)
27. Folic Acid-Functionalized Gadolinium-Loaded Phase Transition Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging of Hepatocellular Carcinoma, Talanta (2021)
28. Eco-Friendly and Sustainable Synthesis of Biocompatible Nanomaterials for Diagnostic Imaging: Current Challenges and Future Perspectives, Green Chemistry (2020)
29. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
30. Anti-Cd24 Bio Modified Pegylated Gold Nanoparticles As Targeted Computed Tomography Contrast Agent, Advanced Pharmaceutical Bulletin (2018)
31. Bevacizumab and Folic Acid Dual-Targeted Gadolinium-Carbon Dots for Fluorescence/Magnetic Resonance Imaging of Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2021)
32. Fabrication of a Biocompatible & Biodegradable Targeted Theranostic Nanocomposite With Ph-Controlled Drug Release Ability, Journal of Drug Delivery Science and Technology (2022)
33. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
34. Synthesis and Cytotoxicity Assessment of Gold-Coated Magnetic Iron Oxide Nanoparticles, Journal of Biomedical Physics and Engineering (2018)
35. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
36. Synergistic Effect of the Combination of Triethylene-Glycol Modified Fe3o4 Nanoparticles and Ultrasound Wave on Mcf-7 Cells, Journal of Magnetism and Magnetic Materials (2015)
37. Assessment of Ploy Dopamine Coated Fe3o4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection, Anti-Cancer Agents in Medicinal Chemistry (2020)
38. An Overview of the Intracellular Localization of High-Z Nanoradiosensitizers, Progress in Biophysics and Molecular Biology (2022)
39. Novel Nanosized Gd3+-Algd-G2 -C595: In Vivo Dual Selective Muc-1 Positive Tumor Molecular Mr Imaging and Therapeutic Agent, Journal of Nanomedicine and Nanotechnology (2012)
40. Novel Mr Imaging Contrast Agents for Cancer Detection, Journal of Research in Medical Sciences (2009)
41. Imaging and Therapeutic Capabilities of the Aunps@Mnco3/Mn3o4, Coated With Paa and Integrated With Folic Acid, Doxorubicin and Propidium Iodide for Murine Breast Cancer, Journal of Drug Delivery Science and Technology (2022)
42. Use of Nanotechnology in Diagnosis and Treatment of Hepatic Fibrosis: A Review, Current Drug Delivery (2016)
43. Modified Bismuth Nanoparticles: A New Targeted Nanoprobe for Computed Tomography Imaging of Cancer, Cell Journal (2022)
44. Aptamer Modified Nanoprobe for Multimodal Fluorescence/Magnetic Resonance Imaging of Human Ovarian Cancer Cells, Applied Physics A: Materials Science and Processing (2021)
45. Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)